Uptake, localization, and noncarboxylase roles of biotin

Research output: Contribution to journalReview article

125 Citations (Scopus)

Abstract

Evidence is emerging that biotin participates in processes other than classical carboxylation reactions. Specifically, novel roles for biotin in cell signaling, gene expression, and chromatin structure have been identified in recent years. Human cells accumulate biotin by using both the sodium-dependent multivitamin transporter and monocarboxylate transporter 1. These transporters and other biotin-binding proteins partition biotin to compartments involved in biotin signaling: cytoplasm, mitochondria, and nuclei. The activity of cell signals such as biotinyl-AMP, Sp1 and Sp3, nuclear factor (NF)-κB, and receptor tyrosine kinases depends on biotin supply. Consistent with a role for biotin and its catabolites in modulating these cell signals, greater than 2000 biotin-dependent genes have been identified in various human tissues. Many biotin-dependent gene products play roles in signal transduction and localize to the cell nucleus, consistent with a role for biotin in cell signaling. Posttranscriptional events related to ribosomal activity and protein folding may further contribute to effects of biotin on gene expression. Finally, research has shown that biotinidase and holocarboxylase synthetase mediate covalent binding of biotin to histones (DNA-binding proteins), affecting chromatin structure; at least seven biotinylation sites have been identified in human histones. Biotinylation of histones appears to play a role in cell proliferation, gene silencing, and the cellular response to DNA repair. Roles for biotin in cell signaling and chromatin structure are consistent with the notion that biotin has a unique significance in cell biology.

Original languageEnglish (US)
Pages (from-to)175-196
Number of pages22
JournalAnnual Review of Nutrition
Volume25
DOIs
StatePublished - Sep 5 2005

Fingerprint

Biotin
Histones
Chromatin
Biotinylation
Biotinidase
Gene Expression
Ribosomal Proteins
Protein Folding
DNA-Binding Proteins
Gene Silencing
Adenosine Monophosphate
Cytoplasmic and Nuclear Receptors
Cell Nucleus
DNA Repair
Protein-Tyrosine Kinases
Genes
Cell Biology
Signal Transduction
Mitochondria
Cytoplasm

Keywords

  • Biotin
  • Cell signaling
  • Gene expression
  • Histones
  • Transport

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Uptake, localization, and noncarboxylase roles of biotin. / Zempleni, Janos.

In: Annual Review of Nutrition, Vol. 25, 05.09.2005, p. 175-196.

Research output: Contribution to journalReview article

@article{77b45835c3144df78da6a1bf175f06f2,
title = "Uptake, localization, and noncarboxylase roles of biotin",
abstract = "Evidence is emerging that biotin participates in processes other than classical carboxylation reactions. Specifically, novel roles for biotin in cell signaling, gene expression, and chromatin structure have been identified in recent years. Human cells accumulate biotin by using both the sodium-dependent multivitamin transporter and monocarboxylate transporter 1. These transporters and other biotin-binding proteins partition biotin to compartments involved in biotin signaling: cytoplasm, mitochondria, and nuclei. The activity of cell signals such as biotinyl-AMP, Sp1 and Sp3, nuclear factor (NF)-κB, and receptor tyrosine kinases depends on biotin supply. Consistent with a role for biotin and its catabolites in modulating these cell signals, greater than 2000 biotin-dependent genes have been identified in various human tissues. Many biotin-dependent gene products play roles in signal transduction and localize to the cell nucleus, consistent with a role for biotin in cell signaling. Posttranscriptional events related to ribosomal activity and protein folding may further contribute to effects of biotin on gene expression. Finally, research has shown that biotinidase and holocarboxylase synthetase mediate covalent binding of biotin to histones (DNA-binding proteins), affecting chromatin structure; at least seven biotinylation sites have been identified in human histones. Biotinylation of histones appears to play a role in cell proliferation, gene silencing, and the cellular response to DNA repair. Roles for biotin in cell signaling and chromatin structure are consistent with the notion that biotin has a unique significance in cell biology.",
keywords = "Biotin, Cell signaling, Gene expression, Histones, Transport",
author = "Janos Zempleni",
year = "2005",
month = "9",
day = "5",
doi = "10.1146/annurev.nutr.25.121304.131724",
language = "English (US)",
volume = "25",
pages = "175--196",
journal = "Annual Review of Nutrition",
issn = "0199-9885",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Uptake, localization, and noncarboxylase roles of biotin

AU - Zempleni, Janos

PY - 2005/9/5

Y1 - 2005/9/5

N2 - Evidence is emerging that biotin participates in processes other than classical carboxylation reactions. Specifically, novel roles for biotin in cell signaling, gene expression, and chromatin structure have been identified in recent years. Human cells accumulate biotin by using both the sodium-dependent multivitamin transporter and monocarboxylate transporter 1. These transporters and other biotin-binding proteins partition biotin to compartments involved in biotin signaling: cytoplasm, mitochondria, and nuclei. The activity of cell signals such as biotinyl-AMP, Sp1 and Sp3, nuclear factor (NF)-κB, and receptor tyrosine kinases depends on biotin supply. Consistent with a role for biotin and its catabolites in modulating these cell signals, greater than 2000 biotin-dependent genes have been identified in various human tissues. Many biotin-dependent gene products play roles in signal transduction and localize to the cell nucleus, consistent with a role for biotin in cell signaling. Posttranscriptional events related to ribosomal activity and protein folding may further contribute to effects of biotin on gene expression. Finally, research has shown that biotinidase and holocarboxylase synthetase mediate covalent binding of biotin to histones (DNA-binding proteins), affecting chromatin structure; at least seven biotinylation sites have been identified in human histones. Biotinylation of histones appears to play a role in cell proliferation, gene silencing, and the cellular response to DNA repair. Roles for biotin in cell signaling and chromatin structure are consistent with the notion that biotin has a unique significance in cell biology.

AB - Evidence is emerging that biotin participates in processes other than classical carboxylation reactions. Specifically, novel roles for biotin in cell signaling, gene expression, and chromatin structure have been identified in recent years. Human cells accumulate biotin by using both the sodium-dependent multivitamin transporter and monocarboxylate transporter 1. These transporters and other biotin-binding proteins partition biotin to compartments involved in biotin signaling: cytoplasm, mitochondria, and nuclei. The activity of cell signals such as biotinyl-AMP, Sp1 and Sp3, nuclear factor (NF)-κB, and receptor tyrosine kinases depends on biotin supply. Consistent with a role for biotin and its catabolites in modulating these cell signals, greater than 2000 biotin-dependent genes have been identified in various human tissues. Many biotin-dependent gene products play roles in signal transduction and localize to the cell nucleus, consistent with a role for biotin in cell signaling. Posttranscriptional events related to ribosomal activity and protein folding may further contribute to effects of biotin on gene expression. Finally, research has shown that biotinidase and holocarboxylase synthetase mediate covalent binding of biotin to histones (DNA-binding proteins), affecting chromatin structure; at least seven biotinylation sites have been identified in human histones. Biotinylation of histones appears to play a role in cell proliferation, gene silencing, and the cellular response to DNA repair. Roles for biotin in cell signaling and chromatin structure are consistent with the notion that biotin has a unique significance in cell biology.

KW - Biotin

KW - Cell signaling

KW - Gene expression

KW - Histones

KW - Transport

UR - http://www.scopus.com/inward/record.url?scp=21444433993&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21444433993&partnerID=8YFLogxK

U2 - 10.1146/annurev.nutr.25.121304.131724

DO - 10.1146/annurev.nutr.25.121304.131724

M3 - Review article

C2 - 16011464

AN - SCOPUS:21444433993

VL - 25

SP - 175

EP - 196

JO - Annual Review of Nutrition

JF - Annual Review of Nutrition

SN - 0199-9885

ER -