Update on novel monoclonal antibodies and immunoconjugates for the treatment of lymphoproliferative disorders

Lyudmyla Derby, Myron S. Czuczman

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

The year 1997 was pivotal in lymphoma research, as it was the year that the US FDA approved rituximab. Rituximab significantly altered clinical management and outcomes of patients with B-cell malignancies. Despite a high initial response rate, the majority of patients subsequently develop variable degrees of therapeutic resistance to rituximab. Research attempting to understand the mechanisms of rituximab resistance and potential ways to overcome them has given rise to the development of novel targeted immunotherapeutics. This article will update the readers on advances in bioengineering of monoclonal antibodies and immunoconjugates that target CD20, as well as other surface antigens. Some additional novel immunotherapeutics, including small modular immunopharmaceuticals, bispecific monoclonal antibodies, T-cell engaging antibodies and immunoconjugates, will also be discussed.

Original languageEnglish (US)
Pages (from-to)963-979
Number of pages17
JournalFuture Oncology
Volume7
Issue number8
DOIs
Publication statusPublished - Aug 1 2011

    Fingerprint

Keywords

  • CD20
  • immunoconjugate
  • lymphoma
  • monoclonal antibody

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this