Unusually high rate of young-onset pancreatic cancer in the East Nile Delta region of Egypt

Amr S. Soliman, Nabih El-Ghawalby, Farouk Ezzat, Melissa L. Bondy, Ahmed Soultan, Mohamed Abdel-Wahab, Omar Fathy, Gamal Ebidi, Nadia Bassiouni, Ahmed El-Ghawalbi, Bernard Levin, James L. Abbruzzese

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background. Pancreatic cancer is predominantly a disorder of the elderly population in the United States. In Egypt, the disease has traditionally been considered rare, and there has not been a previous publication on its population-based incidence or age distribution. Methods. We reviewed the records of 728 pancreatic cancer patients seen at the Gastrointestinal Surgery Center of Mansoura University in the East Nile Delta region of Egypt between 1995 and 2000. We computed population based, age-specific, and age-adjusted incidence rates in this population and compared them with US incidence rates from the Epidemiology Surveillance and End Results (SEER) Program. We also analyzed clinical characteristics of the patients, as well as their surgical and medical management. Results. Approximately one-fourth of all patients were under age 50. The mean ages of patients who had undergone Whipple's resection, other surgical procedures, and no surgical procedure were 52.9 ± 11.6, 54.11 ± 10.5, and 55.1 ± 14.1 yr, with no statistically significant differences. Age-adjusted incidence rates were higher in Egyptian patients than in US patients under age 65 (7.1/100,000 vs 3.3/100,000) but were much higher in US patients than in Egyptian patients over age 65 (6.6/100,000 vs 59.1/100,000). Clinical management did not differ between patients under and over age 50. Conclusion. The population in the East Nile Delta region of Egypt exhibits an unusually high rate of young-onset pancreatic cancer. Further studies to investigate the epidemiology of pancreatic cancer in this population may provide clues to its etiology.

Original languageEnglish (US)
Pages (from-to)143-151
Number of pages9
JournalInternational Journal of Gastrointestinal Cancer
Volume32
Issue number2-3
StatePublished - Dec 1 2002

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Egypt
Pancreatic Neoplasms
Population
Incidence
SEER Program
Age Distribution
Epidemiology

Keywords

  • Age distribution
  • Egypt
  • Epidemiology
  • Pancreatic cancer
  • Young-onset

ASJC Scopus subject areas

  • Oncology
  • Endocrinology
  • Gastroenterology

Cite this

Soliman, A. S., El-Ghawalby, N., Ezzat, F., Bondy, M. L., Soultan, A., Abdel-Wahab, M., ... Abbruzzese, J. L. (2002). Unusually high rate of young-onset pancreatic cancer in the East Nile Delta region of Egypt. International Journal of Gastrointestinal Cancer, 32(2-3), 143-151.

Unusually high rate of young-onset pancreatic cancer in the East Nile Delta region of Egypt. / Soliman, Amr S.; El-Ghawalby, Nabih; Ezzat, Farouk; Bondy, Melissa L.; Soultan, Ahmed; Abdel-Wahab, Mohamed; Fathy, Omar; Ebidi, Gamal; Bassiouni, Nadia; El-Ghawalbi, Ahmed; Levin, Bernard; Abbruzzese, James L.

In: International Journal of Gastrointestinal Cancer, Vol. 32, No. 2-3, 01.12.2002, p. 143-151.

Research output: Contribution to journalArticle

Soliman, AS, El-Ghawalby, N, Ezzat, F, Bondy, ML, Soultan, A, Abdel-Wahab, M, Fathy, O, Ebidi, G, Bassiouni, N, El-Ghawalbi, A, Levin, B & Abbruzzese, JL 2002, 'Unusually high rate of young-onset pancreatic cancer in the East Nile Delta region of Egypt', International Journal of Gastrointestinal Cancer, vol. 32, no. 2-3, pp. 143-151.
Soliman AS, El-Ghawalby N, Ezzat F, Bondy ML, Soultan A, Abdel-Wahab M et al. Unusually high rate of young-onset pancreatic cancer in the East Nile Delta region of Egypt. International Journal of Gastrointestinal Cancer. 2002 Dec 1;32(2-3):143-151.
Soliman, Amr S. ; El-Ghawalby, Nabih ; Ezzat, Farouk ; Bondy, Melissa L. ; Soultan, Ahmed ; Abdel-Wahab, Mohamed ; Fathy, Omar ; Ebidi, Gamal ; Bassiouni, Nadia ; El-Ghawalbi, Ahmed ; Levin, Bernard ; Abbruzzese, James L. / Unusually high rate of young-onset pancreatic cancer in the East Nile Delta region of Egypt. In: International Journal of Gastrointestinal Cancer. 2002 ; Vol. 32, No. 2-3. pp. 143-151.
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abstract = "Background. Pancreatic cancer is predominantly a disorder of the elderly population in the United States. In Egypt, the disease has traditionally been considered rare, and there has not been a previous publication on its population-based incidence or age distribution. Methods. We reviewed the records of 728 pancreatic cancer patients seen at the Gastrointestinal Surgery Center of Mansoura University in the East Nile Delta region of Egypt between 1995 and 2000. We computed population based, age-specific, and age-adjusted incidence rates in this population and compared them with US incidence rates from the Epidemiology Surveillance and End Results (SEER) Program. We also analyzed clinical characteristics of the patients, as well as their surgical and medical management. Results. Approximately one-fourth of all patients were under age 50. The mean ages of patients who had undergone Whipple's resection, other surgical procedures, and no surgical procedure were 52.9 ± 11.6, 54.11 ± 10.5, and 55.1 ± 14.1 yr, with no statistically significant differences. Age-adjusted incidence rates were higher in Egyptian patients than in US patients under age 65 (7.1/100,000 vs 3.3/100,000) but were much higher in US patients than in Egyptian patients over age 65 (6.6/100,000 vs 59.1/100,000). Clinical management did not differ between patients under and over age 50. Conclusion. The population in the East Nile Delta region of Egypt exhibits an unusually high rate of young-onset pancreatic cancer. Further studies to investigate the epidemiology of pancreatic cancer in this population may provide clues to its etiology.",
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AU - El-Ghawalby, Nabih

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AU - Bondy, Melissa L.

AU - Soultan, Ahmed

AU - Abdel-Wahab, Mohamed

AU - Fathy, Omar

AU - Ebidi, Gamal

AU - Bassiouni, Nadia

AU - El-Ghawalbi, Ahmed

AU - Levin, Bernard

AU - Abbruzzese, James L.

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N2 - Background. Pancreatic cancer is predominantly a disorder of the elderly population in the United States. In Egypt, the disease has traditionally been considered rare, and there has not been a previous publication on its population-based incidence or age distribution. Methods. We reviewed the records of 728 pancreatic cancer patients seen at the Gastrointestinal Surgery Center of Mansoura University in the East Nile Delta region of Egypt between 1995 and 2000. We computed population based, age-specific, and age-adjusted incidence rates in this population and compared them with US incidence rates from the Epidemiology Surveillance and End Results (SEER) Program. We also analyzed clinical characteristics of the patients, as well as their surgical and medical management. Results. Approximately one-fourth of all patients were under age 50. The mean ages of patients who had undergone Whipple's resection, other surgical procedures, and no surgical procedure were 52.9 ± 11.6, 54.11 ± 10.5, and 55.1 ± 14.1 yr, with no statistically significant differences. Age-adjusted incidence rates were higher in Egyptian patients than in US patients under age 65 (7.1/100,000 vs 3.3/100,000) but were much higher in US patients than in Egyptian patients over age 65 (6.6/100,000 vs 59.1/100,000). Clinical management did not differ between patients under and over age 50. Conclusion. The population in the East Nile Delta region of Egypt exhibits an unusually high rate of young-onset pancreatic cancer. Further studies to investigate the epidemiology of pancreatic cancer in this population may provide clues to its etiology.

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