Unusual presentation of "extracavitary" primary effusion lymphoma in previously unknown HIV disease

Bruno C. Medeiros, Lori J. Maness, Frank A. Bauer, Jack W. Ross, Dinesh Kapur

Research output: Contribution to journalArticle

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Abstract

Human herpes virus, type 8, also called Kaposi's sarcoma-associated virus, is associated with primary effusion lymphoma, an uncommon and unusual subset of acquired immunodeficiency syndrome-related lymphomas mostly confined to body cavities, which primarily affects human immunodeficiency virus-positive men. We report the case of a 40-year-old male with primary effusion lymphoma that presented initially with generalized lymphadenopathy and hepatosplenomegaly, followed by pericardial effusion and cardiac tamponade, in a previously undiagnosed human immunodeficiency virus patient. Cytomorphological studies disclosed a large-cell lymphoma with a population of cells demonstrating intermediate CD45 expression and partial coexpression of CD20 and CD23 markers, as well as universal expression of HLA-DR, CD71, CD38, and CD-30. Molecular studies showed clonal B-cell gene rearrangements and molecular evidence of human herpes virus, type 8. This case stresses the necessity, even in the absence of the 'classical clinical features,' of molecular testing for human herpes virus, type 8 in a subset of patients with high risk for human herpes virus, type 8-associated lymphomas.

Original languageEnglish (US)
Pages (from-to)591-594
Number of pages4
JournalConnecticut Medicine
Volume64
Issue number10
StatePublished - Oct 1 2000

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Primary Effusion Lymphoma
HIV
Viruses
Lymphoma
Cardiac Tamponade
B-Lymphocyte Gene Rearrangement
Satellite Viruses
Pericardial Effusion
Kaposi's Sarcoma
HLA-DR Antigens
Acquired Immunodeficiency Syndrome
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Unusual presentation of "extracavitary" primary effusion lymphoma in previously unknown HIV disease. / Medeiros, Bruno C.; Maness, Lori J.; Bauer, Frank A.; Ross, Jack W.; Kapur, Dinesh.

In: Connecticut Medicine, Vol. 64, No. 10, 01.10.2000, p. 591-594.

Research output: Contribution to journalArticle

Medeiros, Bruno C. ; Maness, Lori J. ; Bauer, Frank A. ; Ross, Jack W. ; Kapur, Dinesh. / Unusual presentation of "extracavitary" primary effusion lymphoma in previously unknown HIV disease. In: Connecticut Medicine. 2000 ; Vol. 64, No. 10. pp. 591-594.
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