Unusual form of endobronchial aspergillosis in a patient with cystic fibrosis

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The isolation of Aspergillus fumigatus from airway secretions from patients with cystic fibrosis (CF) is common and usually denotes asymptomatic colonization or allergic broncho‐pulmonary aspergillosis (ABPA). A 12‐year‐old boy with CF acutely developed moderately severe symptoms of unremitting cough, fever, dyspnea, weight loss, and cyanosis. Chest radiographs demonstrated widespread unilateral infiltrates and volume loss. By bronchoscopy tenacious mucous plugs were seen occluding the left lower lobe bronchus. Cultures from sputum and sequential bronchoalveolar lavage grew Aspergillus fumigatus, but other significant criteria for diagnosing APBA were lacking. No improvement was seen with a 3 week course of systemic corticosteroid and antibiotic therapy. Treatment with amphotericin B and short‐term mechanical ventilation resulted in rapid resolution of all symptoms. This form of endobronchial aspergillosis has not been described previously. Pediatr Pulmonol. 1993; 16:69–73. © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)69-73
Number of pages5
JournalPediatric Pulmonology
Volume16
Issue number1
DOIs
StatePublished - Jul 1993

Fingerprint

Aspergillus fumigatus
Aspergillosis
Cystic Fibrosis
Allergic Bronchopulmonary Aspergillosis
Cyanosis
Bronchoscopy
Amphotericin B
Bronchoalveolar Lavage
Bronchi
Sputum
Artificial Respiration
Cough
Dyspnea
Weight Loss
Adrenal Cortex Hormones
Fever
Thorax
Anti-Bacterial Agents
Therapeutics

Keywords

  • Allergic broncho‐pulmonary aspergillosis
  • Aspergillus fumigatus
  • CF
  • amphotericin B

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Unusual form of endobronchial aspergillosis in a patient with cystic fibrosis. / Sammut, Paul Henry; Howard, S. T.; Linder, James; Colombo, John Louis.

In: Pediatric Pulmonology, Vol. 16, No. 1, 07.1993, p. 69-73.

Research output: Contribution to journalArticle

@article{ef651eddb352400d856be8fa1e3472f0,
title = "Unusual form of endobronchial aspergillosis in a patient with cystic fibrosis",
abstract = "The isolation of Aspergillus fumigatus from airway secretions from patients with cystic fibrosis (CF) is common and usually denotes asymptomatic colonization or allergic broncho‐pulmonary aspergillosis (ABPA). A 12‐year‐old boy with CF acutely developed moderately severe symptoms of unremitting cough, fever, dyspnea, weight loss, and cyanosis. Chest radiographs demonstrated widespread unilateral infiltrates and volume loss. By bronchoscopy tenacious mucous plugs were seen occluding the left lower lobe bronchus. Cultures from sputum and sequential bronchoalveolar lavage grew Aspergillus fumigatus, but other significant criteria for diagnosing APBA were lacking. No improvement was seen with a 3 week course of systemic corticosteroid and antibiotic therapy. Treatment with amphotericin B and short‐term mechanical ventilation resulted in rapid resolution of all symptoms. This form of endobronchial aspergillosis has not been described previously. Pediatr Pulmonol. 1993; 16:69–73. {\circledC} 1993 Wiley‐Liss, Inc.",
keywords = "Allergic broncho‐pulmonary aspergillosis, Aspergillus fumigatus, CF, amphotericin B",
author = "Sammut, {Paul Henry} and Howard, {S. T.} and James Linder and Colombo, {John Louis}",
year = "1993",
month = "7",
doi = "10.1002/ppul.1950160114",
language = "English (US)",
volume = "16",
pages = "69--73",
journal = "Pediatric Pulmonology",
issn = "8755-6863",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Unusual form of endobronchial aspergillosis in a patient with cystic fibrosis

AU - Sammut, Paul Henry

AU - Howard, S. T.

AU - Linder, James

AU - Colombo, John Louis

PY - 1993/7

Y1 - 1993/7

N2 - The isolation of Aspergillus fumigatus from airway secretions from patients with cystic fibrosis (CF) is common and usually denotes asymptomatic colonization or allergic broncho‐pulmonary aspergillosis (ABPA). A 12‐year‐old boy with CF acutely developed moderately severe symptoms of unremitting cough, fever, dyspnea, weight loss, and cyanosis. Chest radiographs demonstrated widespread unilateral infiltrates and volume loss. By bronchoscopy tenacious mucous plugs were seen occluding the left lower lobe bronchus. Cultures from sputum and sequential bronchoalveolar lavage grew Aspergillus fumigatus, but other significant criteria for diagnosing APBA were lacking. No improvement was seen with a 3 week course of systemic corticosteroid and antibiotic therapy. Treatment with amphotericin B and short‐term mechanical ventilation resulted in rapid resolution of all symptoms. This form of endobronchial aspergillosis has not been described previously. Pediatr Pulmonol. 1993; 16:69–73. © 1993 Wiley‐Liss, Inc.

AB - The isolation of Aspergillus fumigatus from airway secretions from patients with cystic fibrosis (CF) is common and usually denotes asymptomatic colonization or allergic broncho‐pulmonary aspergillosis (ABPA). A 12‐year‐old boy with CF acutely developed moderately severe symptoms of unremitting cough, fever, dyspnea, weight loss, and cyanosis. Chest radiographs demonstrated widespread unilateral infiltrates and volume loss. By bronchoscopy tenacious mucous plugs were seen occluding the left lower lobe bronchus. Cultures from sputum and sequential bronchoalveolar lavage grew Aspergillus fumigatus, but other significant criteria for diagnosing APBA were lacking. No improvement was seen with a 3 week course of systemic corticosteroid and antibiotic therapy. Treatment with amphotericin B and short‐term mechanical ventilation resulted in rapid resolution of all symptoms. This form of endobronchial aspergillosis has not been described previously. Pediatr Pulmonol. 1993; 16:69–73. © 1993 Wiley‐Liss, Inc.

KW - Allergic broncho‐pulmonary aspergillosis

KW - Aspergillus fumigatus

KW - CF

KW - amphotericin B

UR - http://www.scopus.com/inward/record.url?scp=0027637342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027637342&partnerID=8YFLogxK

U2 - 10.1002/ppul.1950160114

DO - 10.1002/ppul.1950160114

M3 - Article

C2 - 8414745

AN - SCOPUS:0027637342

VL - 16

SP - 69

EP - 73

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

SN - 8755-6863

IS - 1

ER -