Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes

Gregory A. Curt, Desmond N. Carney, Kenneth H Cowan, Jacques Jolivet, Brenda D. Bailey, James C. Drake, Chien Song Kao-Shan, John D. Minna, Bruce A. Chabner

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Resistance to antineoplastic drugs may develop through a variety of mechanisms, including deletion of membrane-transport mechanisms, an increase in target-enzyme concentration, or a deletion of an essential drug-activating enzyme. One unique mechanism for mutation to drug resistance is amplification of the gene coding for a target protein, leading to elevated levels of the protein. In studies of cultured experimental tumor-cell lines, resistance to a variety of toxic substances, including cadmium1 and the antineoplastic drugs N-phosphonacetyl-L-aspartate2 and methotrexate,3 has been ascribed to gene amplification. The process of gene amplification in methotrexate-resistant mammalian cells may occur within a single chromosome, producing an.

Original languageEnglish (US)
Pages (from-to)199-202
Number of pages4
JournalNew England Journal of Medicine
Volume308
Issue number4
DOIs
StatePublished - Jan 27 1983

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Small Cell Carcinoma
Gene Amplification
Methotrexate
Chromosomes
Neoplasm Drug Resistance
Essential Drugs
Cultured Tumor Cells
Poisons
Enzymes
Tumor Cell Line
Drug Resistance
Antineoplastic Agents
Proteins
Mutation
Membranes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes. / Curt, Gregory A.; Carney, Desmond N.; Cowan, Kenneth H; Jolivet, Jacques; Bailey, Brenda D.; Drake, James C.; Kao-Shan, Chien Song; Minna, John D.; Chabner, Bruce A.

In: New England Journal of Medicine, Vol. 308, No. 4, 27.01.1983, p. 199-202.

Research output: Contribution to journalArticle

Curt, GA, Carney, DN, Cowan, KH, Jolivet, J, Bailey, BD, Drake, JC, Kao-Shan, CS, Minna, JD & Chabner, BA 1983, 'Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes', New England Journal of Medicine, vol. 308, no. 4, pp. 199-202. https://doi.org/10.1056/NEJM198301273080406
Curt, Gregory A. ; Carney, Desmond N. ; Cowan, Kenneth H ; Jolivet, Jacques ; Bailey, Brenda D. ; Drake, James C. ; Kao-Shan, Chien Song ; Minna, John D. ; Chabner, Bruce A. / Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes. In: New England Journal of Medicine. 1983 ; Vol. 308, No. 4. pp. 199-202.
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