Unsedated transnasal EGD

An alternative approach to conventional esophagogastroduodenoscopy for documenting Helicobacter pylori eradication

K. Saeian, W. F. Townsend, Fedja A Rochling, E. Bardan, K. Dua, S. Phadnis, B. E. Dunn, K. Darnell, R. Shaker

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background: The aim of this study was to assess the yield of antral biopsies performed via unsedated transnasal esophagogastroduodenoscopy, a technique that does not require conscious sedation with its concomitant costs and complications, for documentation of Helicobacter pylori eradication. Methods: Nineteen patients who were previously CLO test positive on conventional esophagogastroduodenoscopy and subsequently treated for H pylori infection were enrolled. The subjects had not received antibiotic therapy in the prior month and had no prior gastric surgery. By using a GIF-N30 fiberoptic endoscope and a tiny cup biopsy forceps (1.8 mm diameter), unsedated transnasal endoscopy was performed and antral biopsy specimens were taken for a CLO test, histologic analysis (Dieterle stain), and tissue culture. On the same day, the subjects underwent a carbon 13-labeled area urea breath test. All subjects completed a visual analog scale, rating the acceptability of the unsedated transnasal examination and the previous sedated conventional esophagogastroduodenoscopy. Results: There was no statistically significant difference between the results of the CLO tests (5/19 positive) versus the 13 C-urea breath test (4/19 positive) (p = 0.96), the CLO tests versus histologic findings (5/19 positive) (p = 0.71), or the 13 C-urea breath test versus histologic findings (p = 0.96). All tissue culture results were negative. The overall acceptability of unsedated transnasal esophagogastroduodenoscopy was similar to that of sedated conventional esophagogastroduodenoscopy. Conclusion: Unsedated transnasal esophagogastroduodenoscopy, a technique that eliminates the costs and complications associated with conscious sedation, is a feasible and accurate alternative to conventional esophagogastroduodenoscopy when documentation of H pylori eradication and confirmation of gastric ulcer healing are both indicated.

Original languageEnglish (US)
Pages (from-to)297-301
Number of pages5
JournalGastrointestinal Endoscopy
Volume49
Issue number3 I
DOIs
StatePublished - Jan 1 1999

Fingerprint

Digestive System Endoscopy
Helicobacter pylori
Breath Tests
Conscious Sedation
Urea
Pylorus
Biopsy
Documentation
Costs and Cost Analysis
Endoscopes
Stomach Ulcer
Visual Analog Scale
Surgical Instruments
Endoscopy
Stomach
Coloring Agents
Carbon
Anti-Bacterial Agents
Infection

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Unsedated transnasal EGD : An alternative approach to conventional esophagogastroduodenoscopy for documenting Helicobacter pylori eradication. / Saeian, K.; Townsend, W. F.; Rochling, Fedja A; Bardan, E.; Dua, K.; Phadnis, S.; Dunn, B. E.; Darnell, K.; Shaker, R.

In: Gastrointestinal Endoscopy, Vol. 49, No. 3 I, 01.01.1999, p. 297-301.

Research output: Contribution to journalArticle

Saeian, K. ; Townsend, W. F. ; Rochling, Fedja A ; Bardan, E. ; Dua, K. ; Phadnis, S. ; Dunn, B. E. ; Darnell, K. ; Shaker, R. / Unsedated transnasal EGD : An alternative approach to conventional esophagogastroduodenoscopy for documenting Helicobacter pylori eradication. In: Gastrointestinal Endoscopy. 1999 ; Vol. 49, No. 3 I. pp. 297-301.
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