Unpacking the association

Individual differences in the relation of prenatal exposure to cigarettes and disruptive behavior phenotypes

Lauren S. Wakschlag, David B. Henry, Robert James Blair, Vanja Dukic, James Burns, Kate E. Pickett

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Prenatal exposure to cigarettes has been robustly associated with disruptive behavior in diverse samples and across developmental periods. In this paper we aim to elucidate exposure related behavioral phenotypes and developmental pathways by testing: (a) differential associations of exposure and four disruptive behavior dimensional phenotypes: Aggression, Noncompliance, Temper Loss and Low Concern for Others; and (b) moderation of these pathways including sex differences and moderation by parental responsive engagement. Participants were 211 teens and their parents from the East Boston Family Study (EBFS), an adolescent follow-up of a pregnancy cohort over-sampled for exposure. A best estimate serum cotinine corrected score was used to characterize exposure. In multivariate models controlling for parental antisocial behavior, family adversity and secondhand exposure, exposure uniquely predicted Aggression and Noncompliance. Paternal responsiveness moderated exposure effects on disruptive behavior. There were no sex differences in these patterns. Phenotypic findings suggest the possibility of specific neural mechanisms. In conjunction with prior research, protective effects of parental responsiveness occurring as late as adolescence point to the potential benefit of parenting-based prevention efforts to reduce risk to exposed offspring.

Original languageEnglish (US)
Pages (from-to)145-154
Number of pages10
JournalNeurotoxicology and Teratology
Volume33
Issue number1
DOIs
StatePublished - Jan 1 2011

Fingerprint

Cotinine
Individuality
Tobacco Products
Aggression
Phenotype
Sex Characteristics
Testing
Parenting
Parents
Pregnancy
Serum
Research
Problem Behavior

Keywords

  • Developmental pathways
  • Disruptive behavior
  • Maternal smoking
  • Parental responsiveness
  • Prenatal exposure to cigarettes
  • Sex differences

ASJC Scopus subject areas

  • Toxicology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Unpacking the association : Individual differences in the relation of prenatal exposure to cigarettes and disruptive behavior phenotypes. / Wakschlag, Lauren S.; Henry, David B.; Blair, Robert James; Dukic, Vanja; Burns, James; Pickett, Kate E.

In: Neurotoxicology and Teratology, Vol. 33, No. 1, 01.01.2011, p. 145-154.

Research output: Contribution to journalArticle

Wakschlag, Lauren S. ; Henry, David B. ; Blair, Robert James ; Dukic, Vanja ; Burns, James ; Pickett, Kate E. / Unpacking the association : Individual differences in the relation of prenatal exposure to cigarettes and disruptive behavior phenotypes. In: Neurotoxicology and Teratology. 2011 ; Vol. 33, No. 1. pp. 145-154.
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