Unlocking the neurogenic potential of mammalian müller glia

Xiaohuan Xia, Iqbal Ahmad

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Müller glia (MG) are the primary support cells in the vertebrate retina, regulating homeostasis in one of the most metabolically active tissues. In lower vertebrates such as fish, they respond to injury by proliferating and reprogramming to regenerate retinal neurons. In mammals, MG may also react to injury by proliferating, but they fail to initiate regeneration. The barriers to regeneration could be intrinsic to mammalian MG or the function of the niche that cannot support the MG reprogramming required for lineage conversion or both. Understanding these mechanisms in light of those being discovered in fish may lead to the formulation of strategies to unlock the neurogenic potential of MG and restore regeneration in the mammalian retina.

Original languageEnglish (US)
Pages (from-to)169-175
Number of pages7
JournalInternational Journal of Stem Cells
Volume9
Issue number2
DOIs
Publication statusPublished - Jan 1 2016

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Keywords

  • Lin28
  • MiR-124
  • Müller glia
  • Neurogenesis
  • Regeneration
  • Retina

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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