Unique antibody responses to malondialdehyde-acetaldehyde (MAA)-protein adducts predict coronary artery disease

Daniel R Anderson, Michael J. Duryee, Scott W. Shurmur, John Y Um, Walter D. Bussey, Carlos D. Hunter, Robert P. Garvin, Harlan R. Sayles, Ted R Mikuls, Lynell Warren Klassen, Geoffrey Milton Thiele

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Malondialdehyde-acetaldehyde adducts (MAA) have been implicated in atherosclerosis. The purpose of this study was to investigate the role of MAA in atherosclerotic disease. Serum samples from controls (n = 82) and patients with; nonobstructive coronary artery disease (CAD), (n = 40), acute myocardial infarction (AMI) (n = 42), or coronary artery bypass graft (CABG) surgery due to obstructive multi-vessel CAD (n = 72), were collected and tested for antibody isotypes to MAAmodifed human serum albumin (MAA-HSA). CAD patients had elevated relative levels of IgG and IgA anti-MAA, compared to control patients (p<0.001). AMI patients had a significantly increased relative levels of circulating IgG anti-MAA-HSA antibodies as compared to stable angina (p<0.03) or CABG patients (p<0.003). CABG patients had significantly increased relative levels of circulating IgA anti-MAA-HSA antibodies as compared to non-obstructive CAD (p<0.001) and AMI patients (p<0.001). Additionally, MAA-modified proteins were detected in the tissue of human AMI lesions. In conclusion, the IgM, IgG and IgA anti-MAA-HSA antibody isotypes are differentially and significantly associated with non-obstructive CAD, AMI, or obstructive multi-vessel CAD and may serve as biomarkers of atherosclerotic disease.

Original languageEnglish (US)
Article number0107440
JournalPloS one
Volume9
Issue number9
DOIs
StatePublished - Sep 1 2014

Fingerprint

Acetaldehyde
acetaldehyde
Malondialdehyde
malondialdehyde
Antibody Formation
Coronary Artery Disease
myocardial infarction
antibodies
Antibodies
Myocardial Infarction
coronary vessels
atherosclerosis
Coronary Artery Bypass
Proteins
proteins
Grafts
Transplants
Stable Angina
coronary artery disease
Serum Albumin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Unique antibody responses to malondialdehyde-acetaldehyde (MAA)-protein adducts predict coronary artery disease. / Anderson, Daniel R; Duryee, Michael J.; Shurmur, Scott W.; Um, John Y; Bussey, Walter D.; Hunter, Carlos D.; Garvin, Robert P.; Sayles, Harlan R.; Mikuls, Ted R; Klassen, Lynell Warren; Thiele, Geoffrey Milton.

In: PloS one, Vol. 9, No. 9, 0107440, 01.09.2014.

Research output: Contribution to journalArticle

Anderson, Daniel R ; Duryee, Michael J. ; Shurmur, Scott W. ; Um, John Y ; Bussey, Walter D. ; Hunter, Carlos D. ; Garvin, Robert P. ; Sayles, Harlan R. ; Mikuls, Ted R ; Klassen, Lynell Warren ; Thiele, Geoffrey Milton. / Unique antibody responses to malondialdehyde-acetaldehyde (MAA)-protein adducts predict coronary artery disease. In: PloS one. 2014 ; Vol. 9, No. 9.
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