Unilateral lower limb suspension: Integrative physiological knowledge from the past 20 years (1991-2011)

K. J. Hackney, L. L. Ploutz-Snyder

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

In 1991, Hans Berg and colleagues published the first research investigation using unilateral lower limb suspension (ULLS) as a human model to study the influence of unloading on skeletal muscle. ULLS requires a participant to perform all activities with axillary crutches while wearing one thick-soled shoe. The elevated shoe eliminates ground contact with the adjacent foot, thereby unloading the lower limb. Today, ULLS is a well-known ground-based analog for microgravity. The present review will synthesize the physiological findings from investigations using ULLS to study the deleterious effects of unloading. Compromised human performance and the neuromuscular, musculoskeletal and circulatory mechanisms leading to altered function will be a major emphasis of the work. Results from prolonged bed rest will also be included in order for general comparisons to be made between analogs. Finally, the efficacy of exercise to mitigate the negative consequences of unloading is presented.

Original languageEnglish (US)
Pages (from-to)9-22
Number of pages14
JournalEuropean Journal of Applied Physiology
Volume112
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Lower Extremity
Suspensions
Shoes
Crutches
Weightlessness
Bed Rest
Foot
Skeletal Muscle
Research

Keywords

  • Disuse
  • Inactivity
  • Space flight analogs
  • Unweighting

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

Cite this

Unilateral lower limb suspension : Integrative physiological knowledge from the past 20 years (1991-2011). / Hackney, K. J.; Ploutz-Snyder, L. L.

In: European Journal of Applied Physiology, Vol. 112, No. 1, 01.01.2012, p. 9-22.

Research output: Contribution to journalReview article

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