Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation

Dawn M. Jelley-Gibbs, Deborah M Brown, John P. Dibble, Laura Haynes, Sheri M. Eaton, Susan L. Swain

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

The kinetics of presentation of influenza virus-derived antigens (Ags), resulting in CD4 T cell effector and memory generation, remains undefined. Naive influenza-specific CD4 T cells were transferred into mice at various times after influenza infection to determine the duration and impact of virus-derived Ag presentation. Ag-specific T cell responses were generated even when the donor T cells were transferred 3-4 wk after viral clearance. Transfer of naive CD4 T cells during early phases of infection resulted in a robust expansion of highly differentiated effectors, which then contracted to a small number of memory T cells. Importantly, T cell transfer during later phases of infection resulted in a modest expansion of effectors with intermediate phenotypes, which were capable of persisting as memory with high efficiency. Thus, distinct stages of pathogen-derived Ag presentation may provide a mechanism by which T cell heterogeneity is generated and diverse memory subsets are maintained. JEM

Original languageEnglish (US)
Pages (from-to)697-706
Number of pages10
JournalJournal of Experimental Medicine
Volume202
Issue number5
DOIs
StatePublished - Sep 5 2005

Fingerprint

CD4 Antigens
Antigen Presentation
Human Influenza
T-Lymphocytes
Infection
Orthomyxoviridae
Viruses
Efficiency
Phenotype
Antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation. / Jelley-Gibbs, Dawn M.; Brown, Deborah M; Dibble, John P.; Haynes, Laura; Eaton, Sheri M.; Swain, Susan L.

In: Journal of Experimental Medicine, Vol. 202, No. 5, 05.09.2005, p. 697-706.

Research output: Contribution to journalArticle

Jelley-Gibbs, Dawn M. ; Brown, Deborah M ; Dibble, John P. ; Haynes, Laura ; Eaton, Sheri M. ; Swain, Susan L. / Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation. In: Journal of Experimental Medicine. 2005 ; Vol. 202, No. 5. pp. 697-706.
@article{01d4b21a2cf24cd7914edcac7608750d,
title = "Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation",
abstract = "The kinetics of presentation of influenza virus-derived antigens (Ags), resulting in CD4 T cell effector and memory generation, remains undefined. Naive influenza-specific CD4 T cells were transferred into mice at various times after influenza infection to determine the duration and impact of virus-derived Ag presentation. Ag-specific T cell responses were generated even when the donor T cells were transferred 3-4 wk after viral clearance. Transfer of naive CD4 T cells during early phases of infection resulted in a robust expansion of highly differentiated effectors, which then contracted to a small number of memory T cells. Importantly, T cell transfer during later phases of infection resulted in a modest expansion of effectors with intermediate phenotypes, which were capable of persisting as memory with high efficiency. Thus, distinct stages of pathogen-derived Ag presentation may provide a mechanism by which T cell heterogeneity is generated and diverse memory subsets are maintained. JEM",
author = "Jelley-Gibbs, {Dawn M.} and Brown, {Deborah M} and Dibble, {John P.} and Laura Haynes and Eaton, {Sheri M.} and Swain, {Susan L.}",
year = "2005",
month = "9",
day = "5",
doi = "10.1084/jem.20050227",
language = "English (US)",
volume = "202",
pages = "697--706",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "5",

}

TY - JOUR

T1 - Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation

AU - Jelley-Gibbs, Dawn M.

AU - Brown, Deborah M

AU - Dibble, John P.

AU - Haynes, Laura

AU - Eaton, Sheri M.

AU - Swain, Susan L.

PY - 2005/9/5

Y1 - 2005/9/5

N2 - The kinetics of presentation of influenza virus-derived antigens (Ags), resulting in CD4 T cell effector and memory generation, remains undefined. Naive influenza-specific CD4 T cells were transferred into mice at various times after influenza infection to determine the duration and impact of virus-derived Ag presentation. Ag-specific T cell responses were generated even when the donor T cells were transferred 3-4 wk after viral clearance. Transfer of naive CD4 T cells during early phases of infection resulted in a robust expansion of highly differentiated effectors, which then contracted to a small number of memory T cells. Importantly, T cell transfer during later phases of infection resulted in a modest expansion of effectors with intermediate phenotypes, which were capable of persisting as memory with high efficiency. Thus, distinct stages of pathogen-derived Ag presentation may provide a mechanism by which T cell heterogeneity is generated and diverse memory subsets are maintained. JEM

AB - The kinetics of presentation of influenza virus-derived antigens (Ags), resulting in CD4 T cell effector and memory generation, remains undefined. Naive influenza-specific CD4 T cells were transferred into mice at various times after influenza infection to determine the duration and impact of virus-derived Ag presentation. Ag-specific T cell responses were generated even when the donor T cells were transferred 3-4 wk after viral clearance. Transfer of naive CD4 T cells during early phases of infection resulted in a robust expansion of highly differentiated effectors, which then contracted to a small number of memory T cells. Importantly, T cell transfer during later phases of infection resulted in a modest expansion of effectors with intermediate phenotypes, which were capable of persisting as memory with high efficiency. Thus, distinct stages of pathogen-derived Ag presentation may provide a mechanism by which T cell heterogeneity is generated and diverse memory subsets are maintained. JEM

UR - http://www.scopus.com/inward/record.url?scp=24344435571&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24344435571&partnerID=8YFLogxK

U2 - 10.1084/jem.20050227

DO - 10.1084/jem.20050227

M3 - Article

VL - 202

SP - 697

EP - 706

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 5

ER -