Unexpected High Incidence of Coronary Vasoconstriction in the Reduction of Microvascular Injury Using Sonolysis (ROMIUS) Trial

Sebastiaan T. Roos, Lynda J M Juffermans, Niels van Royen, Albert C. van Rossum, Feng Xie, Yolande Appelman, Thomas Richard Porter, Otto Kamp

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

High-mechanical-index ultrasound and intravenous microbubbles might prove beneficial in treating microvascular obstruction caused by microthrombi after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI). Experiments in animals have revealed that longer-pulse-duration ultrasound is associated with an improvement in microvascular recovery. This trial tested long-pulse-duration, high-mechanical-index ultrasound in STEMI patients. Non-randomly assigned, non-blinded patients were included in this phase 2 trial. The primary endpoint was any side effect possibly related to the ultrasound treatment. The study was aborted after six patients were included; three patients experienced coronary vasoconstriction of the culprit artery, unresponsive to nitroglycerin. Therefore, coronary artery diameter was measured in five pigs. Coronary artery diameters distal to the injury site decreased after application of ultrasound, after balloon injury plus thrombus injection (from 1.89 ± 0.24 mm before to 1.78 ± 0.17 after ultrasound, p = 0.05). Long-pulse-duration ultrasound might cause coronary vasoconstriction distal to the culprit vessel location.

Original languageEnglish (US)
Pages (from-to)1919-1928
Number of pages10
JournalUltrasound in Medicine and Biology
Volume42
Issue number8
DOIs
StatePublished - Aug 1 2016

Fingerprint

vasoconstriction
Vasoconstriction
arteries
incidence
myocardial infarction
pulse duration
Incidence
Wounds and Injuries
Coronary Vessels
nitroglycerin
Microbubbles
swine
Nitroglycerin
Percutaneous Coronary Intervention
balloons
vessels
animals
Thrombosis
Swine
Arteries

Keywords

  • Microvascular obstruction
  • Myocardial infarction
  • Sonothrombolysis
  • Theragnostic ultrasound
  • Ultrasound contrast agents

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Cite this

Unexpected High Incidence of Coronary Vasoconstriction in the Reduction of Microvascular Injury Using Sonolysis (ROMIUS) Trial. / Roos, Sebastiaan T.; Juffermans, Lynda J M; van Royen, Niels; van Rossum, Albert C.; Xie, Feng; Appelman, Yolande; Porter, Thomas Richard; Kamp, Otto.

In: Ultrasound in Medicine and Biology, Vol. 42, No. 8, 01.08.2016, p. 1919-1928.

Research output: Contribution to journalArticle

Roos, Sebastiaan T. ; Juffermans, Lynda J M ; van Royen, Niels ; van Rossum, Albert C. ; Xie, Feng ; Appelman, Yolande ; Porter, Thomas Richard ; Kamp, Otto. / Unexpected High Incidence of Coronary Vasoconstriction in the Reduction of Microvascular Injury Using Sonolysis (ROMIUS) Trial. In: Ultrasound in Medicine and Biology. 2016 ; Vol. 42, No. 8. pp. 1919-1928.
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