Abstract

Gout is one of the most readily manageable of the rheumatic diseases. This article reviews basic pathways in purine metabolism, uric acid handling, and the pathogenic mechanism of clinical gout, as well as the areas in those pathways amenable to intervention. Attention is also given to associated comorbidities, such as hyperuricemia and obesity, hypertension, hyperinsulinemia, and coronary artery disease. The significance of lifestyle modifications, such as weight loss and alcohol reduction, is discussed as an important adjunct to pharmacotherapy in gout. Current and investigational agents used in gout management are also reviewed. Finally, treatment recommendations for acute and chronic gout are suggested.

Original languageEnglish (US)
JournalAmerican Journal of Managed Care
Volume11
Issue numberSUPPL. 15
StatePublished - Nov 1 2005

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Gout
Disease
comorbidity
hypertension
alcohol
Therapeutics
Hyperuricemia
management
Hyperinsulinism
Rheumatic Diseases
Uric Acid
Life Style
Comorbidity
Weight Loss
Coronary Artery Disease
Obesity
Alcohols
Hypertension
Drug Therapy

ASJC Scopus subject areas

  • Nursing(all)
  • Medicine(all)
  • Health(social science)
  • Health Professions(all)

Cite this

Understanding treatments for gout. / Cannella, Amy C; Mikuls, Ted R.

In: American Journal of Managed Care, Vol. 11, No. SUPPL. 15, 01.11.2005.

Research output: Contribution to journalReview article

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