Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes

Signe Holm Nielsen, Alan J. Mouton, Kristine Y. DeLeon-Pennell, Federica Genovese, Morten Karsdal, Merry L. Lindsey

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Cardiovascular Disease (CVD) is the most common cause of death in industrialized countries, and myocardial infarction (MI) is a major CVD with significant morbidity and mortality. Following MI, the left ventricle (LV) undergoes a wound healing response to ischemia that results in extracellular matrix (ECM) scar formation to replace necrotic myocytes. While ECM accumulation following MI is termed cardiac fibrosis, this is a generic term that does not differentiate between ECM accumulation that occurs in the infarct region to form a scar that is structurally necessary to preserve left ventricle (LV) wall integrity and ECM accumulation that increases LV wall stiffness to exacerbate dilation and stimulate the progression to heart failure. This review focuses on post-MI LV ECM remodeling, targeting the discussion on ECM biomarkers that could be useful for predicting MI outcomes.

Original languageEnglish (US)
Pages (from-to)43-57
Number of pages15
JournalMatrix Biology
Volume75-76
DOIs
StatePublished - Jan 2019

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Keywords

  • Biomarkers
  • Collagen
  • Extracellular matrix
  • Matrix metalloproteinases
  • Myocardial infarction

ASJC Scopus subject areas

  • Molecular Biology

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