Ultrasound, microbubbles, and thrombolysis

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Although dissolution of thrombus using ultrasound has been attempted for over 25 years, the clinical use of this technique remains limited. The ability of microbubbles to potentiate ultrasound-induced thrombolysis has renewed interest in this technique, which recanalizes occluded vessels without the need for fibrinolytic therapy. In this article, the potential mechanisms by which ultrasound and microbubbles produce thrombus dissolution are explored. In vitro and in vivo studies using ultrasound alone and ultrasound in combination with microbubbles to cause thrombolysis are reviewed. Potential clinical implications of more recent findings are explored.

Original languageEnglish (US)
Pages (from-to)101-110
Number of pages10
JournalProgress in Cardiovascular Diseases
Volume44
Issue number2
DOIs
StatePublished - Jan 1 2001

Fingerprint

Microbubbles
Thrombosis
Thrombolytic Therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ultrasound, microbubbles, and thrombolysis. / Porter, Thomas Richard; Xie, Feng.

In: Progress in Cardiovascular Diseases, Vol. 44, No. 2, 01.01.2001, p. 101-110.

Research output: Contribution to journalArticle

@article{e1336942923d453588e87fa153e15dbd,
title = "Ultrasound, microbubbles, and thrombolysis",
abstract = "Although dissolution of thrombus using ultrasound has been attempted for over 25 years, the clinical use of this technique remains limited. The ability of microbubbles to potentiate ultrasound-induced thrombolysis has renewed interest in this technique, which recanalizes occluded vessels without the need for fibrinolytic therapy. In this article, the potential mechanisms by which ultrasound and microbubbles produce thrombus dissolution are explored. In vitro and in vivo studies using ultrasound alone and ultrasound in combination with microbubbles to cause thrombolysis are reviewed. Potential clinical implications of more recent findings are explored.",
author = "Porter, {Thomas Richard} and Feng Xie",
year = "2001",
month = "1",
day = "1",
doi = "10.1053/pcad.2001.26441",
language = "English (US)",
volume = "44",
pages = "101--110",
journal = "Progress in Cardiovascular Diseases",
issn = "0033-0620",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Ultrasound, microbubbles, and thrombolysis

AU - Porter, Thomas Richard

AU - Xie, Feng

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Although dissolution of thrombus using ultrasound has been attempted for over 25 years, the clinical use of this technique remains limited. The ability of microbubbles to potentiate ultrasound-induced thrombolysis has renewed interest in this technique, which recanalizes occluded vessels without the need for fibrinolytic therapy. In this article, the potential mechanisms by which ultrasound and microbubbles produce thrombus dissolution are explored. In vitro and in vivo studies using ultrasound alone and ultrasound in combination with microbubbles to cause thrombolysis are reviewed. Potential clinical implications of more recent findings are explored.

AB - Although dissolution of thrombus using ultrasound has been attempted for over 25 years, the clinical use of this technique remains limited. The ability of microbubbles to potentiate ultrasound-induced thrombolysis has renewed interest in this technique, which recanalizes occluded vessels without the need for fibrinolytic therapy. In this article, the potential mechanisms by which ultrasound and microbubbles produce thrombus dissolution are explored. In vitro and in vivo studies using ultrasound alone and ultrasound in combination with microbubbles to cause thrombolysis are reviewed. Potential clinical implications of more recent findings are explored.

UR - http://www.scopus.com/inward/record.url?scp=0034821925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034821925&partnerID=8YFLogxK

U2 - 10.1053/pcad.2001.26441

DO - 10.1053/pcad.2001.26441

M3 - Article

C2 - 11568822

AN - SCOPUS:0034821925

VL - 44

SP - 101

EP - 110

JO - Progress in Cardiovascular Diseases

JF - Progress in Cardiovascular Diseases

SN - 0033-0620

IS - 2

ER -