Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitis

Henry A. Leder, John P. Campbell, Yasir J. Sepah, Theresa Gan, James P. Dunn, Elham Hatef, Brian Cho, Mohamed Ibrahim, Millena Bittencourt, Roomasa Channa, Diana V. Do, Quan Dong Nguyen

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

Background: The purpose of this study is to describe and quantify the benefit of ultra-wide-field imaging and fluorescein angiography (FA) in the management of non-infectious retinal vasculitis. In this prospective observational cohort series, patients with non-infectious retinal vasculitis were evaluated and enrolled by four investigators from the Divisions of Retina and Ocular Immunology at the Wilmer Eye Institute. In each patient, disease activity and the need for management changes were assessed, based on clinical examination with or without standard (60°) imaging and then with the addition of ultra-wide-field pseudo-color scanning laser ophthalmoscope (SLO) images and FA using the Optos ultra-wide-field SLO (Optos Panoramic 200MA™, Optos PLC, Dunfermline, Scotland, UK). A standardized questionnaire was completed by each investigator at the time of the clinical evaluation. The primary outcome was the percentage of patients whose management was changed by clinical examination and standard FA, compared with clinical examination plus ultra-wide-field imaging. The secondary outcome was the percentage of patients whose disease was determined to be active based on each modality. Results: Seventy-one visits from 23 patients were reviewed and analyzed. Based on examination plus ultra-wide-field imaging and ultra-wide-field angiography, disease activity was detected in 48/71 (68%) compared with 32/71 (45%) based on examination and standard FA (P = 0.0095). Based on the clinical examination alone, the decision to alter management was made in 4 of 71 visits (6%), and an additional 3 of 71 (4%) based on simulated standard FA. The addition of ultra-wide-field SLO pseudo-color images altered management in an additional 10/71 visits (14%), and 36/71 (51%) with the addition of ultra-wide-field FA. Conclusions: Ultra-wide-field fluorescein imaging and angiography can provide additional information that may be important and relevant in the management of retinal vasculitis.

Original languageEnglish (US)
Article number30
Pages (from-to)1-6
Number of pages6
JournalJournal of Ophthalmic Inflammation and Infection
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2013

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Retinal Vasculitis
Fluorescein Angiography
Ophthalmoscopes
Lasers
Color
Research Personnel
Scotland
Allergy and Immunology
Retina
Angiography

Keywords

  • Fluorescein angiography
  • Non-infectious retinal vasculitis
  • Ultra-wide-field imaging

ASJC Scopus subject areas

  • Ophthalmology
  • Infectious Diseases

Cite this

Leder, H. A., Campbell, J. P., Sepah, Y. J., Gan, T., Dunn, J. P., Hatef, E., ... Nguyen, Q. D. (2013). Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitis. Journal of Ophthalmic Inflammation and Infection, 3(1), 1-6. [30]. https://doi.org/10.1186/1869-5760-3-30

Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitis. / Leder, Henry A.; Campbell, John P.; Sepah, Yasir J.; Gan, Theresa; Dunn, James P.; Hatef, Elham; Cho, Brian; Ibrahim, Mohamed; Bittencourt, Millena; Channa, Roomasa; Do, Diana V.; Nguyen, Quan Dong.

In: Journal of Ophthalmic Inflammation and Infection, Vol. 3, No. 1, 30, 01.01.2013, p. 1-6.

Research output: Contribution to journalReview article

Leder, HA, Campbell, JP, Sepah, YJ, Gan, T, Dunn, JP, Hatef, E, Cho, B, Ibrahim, M, Bittencourt, M, Channa, R, Do, DV & Nguyen, QD 2013, 'Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitis', Journal of Ophthalmic Inflammation and Infection, vol. 3, no. 1, 30, pp. 1-6. https://doi.org/10.1186/1869-5760-3-30
Leder, Henry A. ; Campbell, John P. ; Sepah, Yasir J. ; Gan, Theresa ; Dunn, James P. ; Hatef, Elham ; Cho, Brian ; Ibrahim, Mohamed ; Bittencourt, Millena ; Channa, Roomasa ; Do, Diana V. ; Nguyen, Quan Dong. / Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitis. In: Journal of Ophthalmic Inflammation and Infection. 2013 ; Vol. 3, No. 1. pp. 1-6.
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abstract = "Background: The purpose of this study is to describe and quantify the benefit of ultra-wide-field imaging and fluorescein angiography (FA) in the management of non-infectious retinal vasculitis. In this prospective observational cohort series, patients with non-infectious retinal vasculitis were evaluated and enrolled by four investigators from the Divisions of Retina and Ocular Immunology at the Wilmer Eye Institute. In each patient, disease activity and the need for management changes were assessed, based on clinical examination with or without standard (60°) imaging and then with the addition of ultra-wide-field pseudo-color scanning laser ophthalmoscope (SLO) images and FA using the Optos ultra-wide-field SLO (Optos Panoramic 200MA™, Optos PLC, Dunfermline, Scotland, UK). A standardized questionnaire was completed by each investigator at the time of the clinical evaluation. The primary outcome was the percentage of patients whose management was changed by clinical examination and standard FA, compared with clinical examination plus ultra-wide-field imaging. The secondary outcome was the percentage of patients whose disease was determined to be active based on each modality. Results: Seventy-one visits from 23 patients were reviewed and analyzed. Based on examination plus ultra-wide-field imaging and ultra-wide-field angiography, disease activity was detected in 48/71 (68{\%}) compared with 32/71 (45{\%}) based on examination and standard FA (P = 0.0095). Based on the clinical examination alone, the decision to alter management was made in 4 of 71 visits (6{\%}), and an additional 3 of 71 (4{\%}) based on simulated standard FA. The addition of ultra-wide-field SLO pseudo-color images altered management in an additional 10/71 visits (14{\%}), and 36/71 (51{\%}) with the addition of ultra-wide-field FA. Conclusions: Ultra-wide-field fluorescein imaging and angiography can provide additional information that may be important and relevant in the management of retinal vasculitis.",
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AU - Sepah, Yasir J.

AU - Gan, Theresa

AU - Dunn, James P.

AU - Hatef, Elham

AU - Cho, Brian

AU - Ibrahim, Mohamed

AU - Bittencourt, Millena

AU - Channa, Roomasa

AU - Do, Diana V.

AU - Nguyen, Quan Dong

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N2 - Background: The purpose of this study is to describe and quantify the benefit of ultra-wide-field imaging and fluorescein angiography (FA) in the management of non-infectious retinal vasculitis. In this prospective observational cohort series, patients with non-infectious retinal vasculitis were evaluated and enrolled by four investigators from the Divisions of Retina and Ocular Immunology at the Wilmer Eye Institute. In each patient, disease activity and the need for management changes were assessed, based on clinical examination with or without standard (60°) imaging and then with the addition of ultra-wide-field pseudo-color scanning laser ophthalmoscope (SLO) images and FA using the Optos ultra-wide-field SLO (Optos Panoramic 200MA™, Optos PLC, Dunfermline, Scotland, UK). A standardized questionnaire was completed by each investigator at the time of the clinical evaluation. The primary outcome was the percentage of patients whose management was changed by clinical examination and standard FA, compared with clinical examination plus ultra-wide-field imaging. The secondary outcome was the percentage of patients whose disease was determined to be active based on each modality. Results: Seventy-one visits from 23 patients were reviewed and analyzed. Based on examination plus ultra-wide-field imaging and ultra-wide-field angiography, disease activity was detected in 48/71 (68%) compared with 32/71 (45%) based on examination and standard FA (P = 0.0095). Based on the clinical examination alone, the decision to alter management was made in 4 of 71 visits (6%), and an additional 3 of 71 (4%) based on simulated standard FA. The addition of ultra-wide-field SLO pseudo-color images altered management in an additional 10/71 visits (14%), and 36/71 (51%) with the addition of ultra-wide-field FA. Conclusions: Ultra-wide-field fluorescein imaging and angiography can provide additional information that may be important and relevant in the management of retinal vasculitis.

AB - Background: The purpose of this study is to describe and quantify the benefit of ultra-wide-field imaging and fluorescein angiography (FA) in the management of non-infectious retinal vasculitis. In this prospective observational cohort series, patients with non-infectious retinal vasculitis were evaluated and enrolled by four investigators from the Divisions of Retina and Ocular Immunology at the Wilmer Eye Institute. In each patient, disease activity and the need for management changes were assessed, based on clinical examination with or without standard (60°) imaging and then with the addition of ultra-wide-field pseudo-color scanning laser ophthalmoscope (SLO) images and FA using the Optos ultra-wide-field SLO (Optos Panoramic 200MA™, Optos PLC, Dunfermline, Scotland, UK). A standardized questionnaire was completed by each investigator at the time of the clinical evaluation. The primary outcome was the percentage of patients whose management was changed by clinical examination and standard FA, compared with clinical examination plus ultra-wide-field imaging. The secondary outcome was the percentage of patients whose disease was determined to be active based on each modality. Results: Seventy-one visits from 23 patients were reviewed and analyzed. Based on examination plus ultra-wide-field imaging and ultra-wide-field angiography, disease activity was detected in 48/71 (68%) compared with 32/71 (45%) based on examination and standard FA (P = 0.0095). Based on the clinical examination alone, the decision to alter management was made in 4 of 71 visits (6%), and an additional 3 of 71 (4%) based on simulated standard FA. The addition of ultra-wide-field SLO pseudo-color images altered management in an additional 10/71 visits (14%), and 36/71 (51%) with the addition of ultra-wide-field FA. Conclusions: Ultra-wide-field fluorescein imaging and angiography can provide additional information that may be important and relevant in the management of retinal vasculitis.

KW - Fluorescein angiography

KW - Non-infectious retinal vasculitis

KW - Ultra-wide-field imaging

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