Ultra-compliant thermal AFM probes for studying of cellular properties

King Wai Chiu Lai, Angelo Gaitas, Ruiguo Yang, Carmen Kar Man Fung, Ning Xi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Atomic force microscopy (AFM) can be used for a number of nanoscale biological studies. It opens the possibility to monitor cellular processes in physiological conditions with the ability to perform high resolution imaging and force measurements. However, analysis of the mechanical property of the living cells is difficult and the sensitivity is low. Conventional AFM probes use high-stiffness materials and therefore, it makes the force measurement on soft samples becoming more difficult. In this work an ultra-compliant AFM probe made of polyimide was used to provide an improved imaging and force measurement of cancer cells. The probe includes an embedded sensing element for thermal conductance characterization. The probe was used for thermal conductance and topographical mapping of biological cells. The probe allows for high speed imaging of cells in liquids.

Original languageEnglish (US)
Title of host publication2010 10th IEEE Conference on Nanotechnology, NANO 2010
Pages369-372
Number of pages4
DOIs
StatePublished - Dec 1 2010
Event2010 10th IEEE Conference on Nanotechnology, NANO 2010 - Ilsan, Gyeonggi-Do, Korea, Republic of
Duration: Aug 17 2010Aug 20 2010

Publication series

Name2010 10th IEEE Conference on Nanotechnology, NANO 2010

Other

Other2010 10th IEEE Conference on Nanotechnology, NANO 2010
CountryKorea, Republic of
CityIlsan, Gyeonggi-Do
Period8/17/108/20/10

Fingerprint

atomic force microscopy
probes
polyimides
stiffness
cancer
high speed
mechanical properties
sensitivity
high resolution
liquids
cells

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Lai, K. W. C., Gaitas, A., Yang, R., Fung, C. K. M., & Xi, N. (2010). Ultra-compliant thermal AFM probes for studying of cellular properties. In 2010 10th IEEE Conference on Nanotechnology, NANO 2010 (pp. 369-372). [5697767] (2010 10th IEEE Conference on Nanotechnology, NANO 2010). https://doi.org/10.1109/NANO.2010.5697767

Ultra-compliant thermal AFM probes for studying of cellular properties. / Lai, King Wai Chiu; Gaitas, Angelo; Yang, Ruiguo; Fung, Carmen Kar Man; Xi, Ning.

2010 10th IEEE Conference on Nanotechnology, NANO 2010. 2010. p. 369-372 5697767 (2010 10th IEEE Conference on Nanotechnology, NANO 2010).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lai, KWC, Gaitas, A, Yang, R, Fung, CKM & Xi, N 2010, Ultra-compliant thermal AFM probes for studying of cellular properties. in 2010 10th IEEE Conference on Nanotechnology, NANO 2010., 5697767, 2010 10th IEEE Conference on Nanotechnology, NANO 2010, pp. 369-372, 2010 10th IEEE Conference on Nanotechnology, NANO 2010, Ilsan, Gyeonggi-Do, Korea, Republic of, 8/17/10. https://doi.org/10.1109/NANO.2010.5697767
Lai KWC, Gaitas A, Yang R, Fung CKM, Xi N. Ultra-compliant thermal AFM probes for studying of cellular properties. In 2010 10th IEEE Conference on Nanotechnology, NANO 2010. 2010. p. 369-372. 5697767. (2010 10th IEEE Conference on Nanotechnology, NANO 2010). https://doi.org/10.1109/NANO.2010.5697767
Lai, King Wai Chiu ; Gaitas, Angelo ; Yang, Ruiguo ; Fung, Carmen Kar Man ; Xi, Ning. / Ultra-compliant thermal AFM probes for studying of cellular properties. 2010 10th IEEE Conference on Nanotechnology, NANO 2010. 2010. pp. 369-372 (2010 10th IEEE Conference on Nanotechnology, NANO 2010).
@inproceedings{645684060b4f4d938ba5b1a422a8e3bd,
title = "Ultra-compliant thermal AFM probes for studying of cellular properties",
abstract = "Atomic force microscopy (AFM) can be used for a number of nanoscale biological studies. It opens the possibility to monitor cellular processes in physiological conditions with the ability to perform high resolution imaging and force measurements. However, analysis of the mechanical property of the living cells is difficult and the sensitivity is low. Conventional AFM probes use high-stiffness materials and therefore, it makes the force measurement on soft samples becoming more difficult. In this work an ultra-compliant AFM probe made of polyimide was used to provide an improved imaging and force measurement of cancer cells. The probe includes an embedded sensing element for thermal conductance characterization. The probe was used for thermal conductance and topographical mapping of biological cells. The probe allows for high speed imaging of cells in liquids.",
author = "Lai, {King Wai Chiu} and Angelo Gaitas and Ruiguo Yang and Fung, {Carmen Kar Man} and Ning Xi",
year = "2010",
month = "12",
day = "1",
doi = "10.1109/NANO.2010.5697767",
language = "English (US)",
isbn = "9781424470334",
series = "2010 10th IEEE Conference on Nanotechnology, NANO 2010",
pages = "369--372",
booktitle = "2010 10th IEEE Conference on Nanotechnology, NANO 2010",

}

TY - GEN

T1 - Ultra-compliant thermal AFM probes for studying of cellular properties

AU - Lai, King Wai Chiu

AU - Gaitas, Angelo

AU - Yang, Ruiguo

AU - Fung, Carmen Kar Man

AU - Xi, Ning

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Atomic force microscopy (AFM) can be used for a number of nanoscale biological studies. It opens the possibility to monitor cellular processes in physiological conditions with the ability to perform high resolution imaging and force measurements. However, analysis of the mechanical property of the living cells is difficult and the sensitivity is low. Conventional AFM probes use high-stiffness materials and therefore, it makes the force measurement on soft samples becoming more difficult. In this work an ultra-compliant AFM probe made of polyimide was used to provide an improved imaging and force measurement of cancer cells. The probe includes an embedded sensing element for thermal conductance characterization. The probe was used for thermal conductance and topographical mapping of biological cells. The probe allows for high speed imaging of cells in liquids.

AB - Atomic force microscopy (AFM) can be used for a number of nanoscale biological studies. It opens the possibility to monitor cellular processes in physiological conditions with the ability to perform high resolution imaging and force measurements. However, analysis of the mechanical property of the living cells is difficult and the sensitivity is low. Conventional AFM probes use high-stiffness materials and therefore, it makes the force measurement on soft samples becoming more difficult. In this work an ultra-compliant AFM probe made of polyimide was used to provide an improved imaging and force measurement of cancer cells. The probe includes an embedded sensing element for thermal conductance characterization. The probe was used for thermal conductance and topographical mapping of biological cells. The probe allows for high speed imaging of cells in liquids.

UR - http://www.scopus.com/inward/record.url?scp=79951846724&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951846724&partnerID=8YFLogxK

U2 - 10.1109/NANO.2010.5697767

DO - 10.1109/NANO.2010.5697767

M3 - Conference contribution

SN - 9781424470334

T3 - 2010 10th IEEE Conference on Nanotechnology, NANO 2010

SP - 369

EP - 372

BT - 2010 10th IEEE Conference on Nanotechnology, NANO 2010

ER -