Typhoid fever: Tracking the trend in Nigeria

Kabiru Olusegun Akinyemi, Akeeb Oriowo Bola Oyefolu, Wasiu Bamidele Mutiu, Bamidele Abiodun Iwalokun, Edward Sunday Ayeni, Samuel Oluwasegun Ajose, Stephen K Obaro

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Typhoid fever continues to pose a serious health challenge in developing countries. A reliable database on positive blood cultures is essential for prompt interventions. To generate reliable data on Salmonella enterica serovar Typhi (S. Typhi)-positive blood culture trends in typhoidal Salmonella in Nigeria alongside changing contextual factors and antimicrobial resistance patterns, a retrospective cohort study was conducted in two hospitals in Lagos between 1993 and 2015. Medical records of typhoid patients were reviewed for positive culture and antibiogram, using standard procedures and analyzed. Additional data were retrieved from a previous study in seven facilities in Abuja and three hospitals in Kano from 2008 to 2017 and 2013 to 2017, respectively. A declining trend in percent positivity of S. Typhi was observed in Abuja with more erratic trends in Lagos and Kano. In Lagos, more than 80% of the isolates from the entire study period exhibited multiple drug resistance with a generally increasing trend. Of the chosen contextual factors, improvements were recorded in female literacy, access to improved water supply, diarrheal mortality in children younger than 5 years, gross domestic product, and poverty while access to improved sanitation facilities decreased over time nationally. Typhoid fever still poses a serious health challenge in Nigeria and in antibiotic resistance, and is a major health security issue. A combined approach that includes the use of typhoid vaccines, improvements in sanitation, and safe water supply is essential.

Original languageEnglish (US)
Pages (from-to)41-47
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume99
Issue number3
DOIs
StatePublished - Jan 1 2018

Fingerprint

Typhoid Fever
Nigeria
Sanitation
Water Supply
Health
Typhoid-Paratyphoid Vaccines
Gross Domestic Product
Child Mortality
Salmonella typhi
R Factors
Microbial Sensitivity Tests
Multiple Drug Resistance
Poverty
Microbial Drug Resistance
Salmonella
Developing Countries
Medical Records
Cohort Studies
Retrospective Studies
Databases

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Cite this

Akinyemi, K. O., Oyefolu, A. O. B., Mutiu, W. B., Iwalokun, B. A., Ayeni, E. S., Ajose, S. O., & Obaro, S. K. (2018). Typhoid fever: Tracking the trend in Nigeria. American Journal of Tropical Medicine and Hygiene, 99(3), 41-47. https://doi.org/10.4269/ajtmh.18-0045

Typhoid fever : Tracking the trend in Nigeria. / Akinyemi, Kabiru Olusegun; Oyefolu, Akeeb Oriowo Bola; Mutiu, Wasiu Bamidele; Iwalokun, Bamidele Abiodun; Ayeni, Edward Sunday; Ajose, Samuel Oluwasegun; Obaro, Stephen K.

In: American Journal of Tropical Medicine and Hygiene, Vol. 99, No. 3, 01.01.2018, p. 41-47.

Research output: Contribution to journalArticle

Akinyemi, KO, Oyefolu, AOB, Mutiu, WB, Iwalokun, BA, Ayeni, ES, Ajose, SO & Obaro, SK 2018, 'Typhoid fever: Tracking the trend in Nigeria', American Journal of Tropical Medicine and Hygiene, vol. 99, no. 3, pp. 41-47. https://doi.org/10.4269/ajtmh.18-0045
Akinyemi KO, Oyefolu AOB, Mutiu WB, Iwalokun BA, Ayeni ES, Ajose SO et al. Typhoid fever: Tracking the trend in Nigeria. American Journal of Tropical Medicine and Hygiene. 2018 Jan 1;99(3):41-47. https://doi.org/10.4269/ajtmh.18-0045
Akinyemi, Kabiru Olusegun ; Oyefolu, Akeeb Oriowo Bola ; Mutiu, Wasiu Bamidele ; Iwalokun, Bamidele Abiodun ; Ayeni, Edward Sunday ; Ajose, Samuel Oluwasegun ; Obaro, Stephen K. / Typhoid fever : Tracking the trend in Nigeria. In: American Journal of Tropical Medicine and Hygiene. 2018 ; Vol. 99, No. 3. pp. 41-47.
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