Typhlitis resulting from treatment with taxol and doxorubicin in patients with metastatic breast cancer

Bernhard C. Pestalozzi, George A. Sotos, Peter L. Choyke, Jason S. Fisherman, Kenneth H. Cowan, Joyce A. O'Shaughnessy

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Background. Typhlitis is being recognized with increasing frequency as a serious complication of aggressive chemotherapy for hematologic and solid malignancies. Methods. In this report the authors describe two cases of typhlitis in patients with metastatic breast cancer treated with taxol and doxorubicin. Results. Both cases occurred during the first cycle of treatment with taxol (180 mg/m2) and doxorubicin (75 mg/m2), being given simultaneously as 72‐hour continuous intravenous infusions. Conclusion. Two cases of typhlitis have occurred after combined treatment with taxol and doxorubicin, while typhlitis has not been described after treatment with either drug alone.

Original languageEnglish (US)
Pages (from-to)1797-1800
Number of pages4
JournalCancer
Volume71
Issue number5
DOIs
StatePublished - Mar 1 1993

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Typhlitis
Paclitaxel
Doxorubicin
Breast Neoplasms
Hematologic Neoplasms
Therapeutics
Intravenous Infusions
Drug Therapy
Pharmaceutical Preparations

Keywords

  • doxorubicin
  • metastatic breast cancer
  • taxol
  • typhlitis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Typhlitis resulting from treatment with taxol and doxorubicin in patients with metastatic breast cancer. / Pestalozzi, Bernhard C.; Sotos, George A.; Choyke, Peter L.; Fisherman, Jason S.; Cowan, Kenneth H.; O'Shaughnessy, Joyce A.

In: Cancer, Vol. 71, No. 5, 01.03.1993, p. 1797-1800.

Research output: Contribution to journalArticle

Pestalozzi, Bernhard C. ; Sotos, George A. ; Choyke, Peter L. ; Fisherman, Jason S. ; Cowan, Kenneth H. ; O'Shaughnessy, Joyce A. / Typhlitis resulting from treatment with taxol and doxorubicin in patients with metastatic breast cancer. In: Cancer. 1993 ; Vol. 71, No. 5. pp. 1797-1800.
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