Two pathways of costimulation through CD28

Jim Miller, Christina Baker, Kevin Cook, Beth Graf, Mariano Sanchez-Lockhart, Katherine Sharp, Xia Wang, Barbara Yang, Takeshi Yoshida

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

CD28 is recognized as the primary costimulatory molecule involved in the activation of naïve T cells. However, the biochemical signaling pathways that are activated by CD28 and how these pathways are integrated with TCR signaling are still not understood. We have recently shown that there are at least two independent activation pathways induced by CD28 costimulation. One is integrated with TCR signaling in the context of the immunological synapse and is mediated through transcriptional enhancement and the second is mediated through the induction of mRNA stability. Here, we review the immunological consequences and biochemical mechanisms associated with CD28 costimulation and discuss the major questions that need to be resolved to understand the molecular mechanisms that transduce CD28 costimulation.

Original languageEnglish (US)
Pages (from-to)159-172
Number of pages14
JournalImmunologic Research
Volume45
Issue number2-3
DOIs
StatePublished - Dec 1 2009

Fingerprint

Immunological Synapses
RNA Stability
T-Lymphocytes

Keywords

  • Antigen presentation
  • CD28
  • Costimulation
  • Immunological synapse
  • MRNA stability
  • Signal transduction
  • T cells
  • Transcriptional regulation

ASJC Scopus subject areas

  • Immunology

Cite this

Miller, J., Baker, C., Cook, K., Graf, B., Sanchez-Lockhart, M., Sharp, K., ... Yoshida, T. (2009). Two pathways of costimulation through CD28. Immunologic Research, 45(2-3), 159-172. https://doi.org/10.1007/s12026-009-8097-6

Two pathways of costimulation through CD28. / Miller, Jim; Baker, Christina; Cook, Kevin; Graf, Beth; Sanchez-Lockhart, Mariano; Sharp, Katherine; Wang, Xia; Yang, Barbara; Yoshida, Takeshi.

In: Immunologic Research, Vol. 45, No. 2-3, 01.12.2009, p. 159-172.

Research output: Contribution to journalReview article

Miller, J, Baker, C, Cook, K, Graf, B, Sanchez-Lockhart, M, Sharp, K, Wang, X, Yang, B & Yoshida, T 2009, 'Two pathways of costimulation through CD28', Immunologic Research, vol. 45, no. 2-3, pp. 159-172. https://doi.org/10.1007/s12026-009-8097-6
Miller J, Baker C, Cook K, Graf B, Sanchez-Lockhart M, Sharp K et al. Two pathways of costimulation through CD28. Immunologic Research. 2009 Dec 1;45(2-3):159-172. https://doi.org/10.1007/s12026-009-8097-6
Miller, Jim ; Baker, Christina ; Cook, Kevin ; Graf, Beth ; Sanchez-Lockhart, Mariano ; Sharp, Katherine ; Wang, Xia ; Yang, Barbara ; Yoshida, Takeshi. / Two pathways of costimulation through CD28. In: Immunologic Research. 2009 ; Vol. 45, No. 2-3. pp. 159-172.
@article{fc0f7491206b48168bca63f298fc6559,
title = "Two pathways of costimulation through CD28",
abstract = "CD28 is recognized as the primary costimulatory molecule involved in the activation of na{\"i}ve T cells. However, the biochemical signaling pathways that are activated by CD28 and how these pathways are integrated with TCR signaling are still not understood. We have recently shown that there are at least two independent activation pathways induced by CD28 costimulation. One is integrated with TCR signaling in the context of the immunological synapse and is mediated through transcriptional enhancement and the second is mediated through the induction of mRNA stability. Here, we review the immunological consequences and biochemical mechanisms associated with CD28 costimulation and discuss the major questions that need to be resolved to understand the molecular mechanisms that transduce CD28 costimulation.",
keywords = "Antigen presentation, CD28, Costimulation, Immunological synapse, MRNA stability, Signal transduction, T cells, Transcriptional regulation",
author = "Jim Miller and Christina Baker and Kevin Cook and Beth Graf and Mariano Sanchez-Lockhart and Katherine Sharp and Xia Wang and Barbara Yang and Takeshi Yoshida",
year = "2009",
month = "12",
day = "1",
doi = "10.1007/s12026-009-8097-6",
language = "English (US)",
volume = "45",
pages = "159--172",
journal = "Immunologic Research",
issn = "0257-277X",
publisher = "Humana Press",
number = "2-3",

}

TY - JOUR

T1 - Two pathways of costimulation through CD28

AU - Miller, Jim

AU - Baker, Christina

AU - Cook, Kevin

AU - Graf, Beth

AU - Sanchez-Lockhart, Mariano

AU - Sharp, Katherine

AU - Wang, Xia

AU - Yang, Barbara

AU - Yoshida, Takeshi

PY - 2009/12/1

Y1 - 2009/12/1

N2 - CD28 is recognized as the primary costimulatory molecule involved in the activation of naïve T cells. However, the biochemical signaling pathways that are activated by CD28 and how these pathways are integrated with TCR signaling are still not understood. We have recently shown that there are at least two independent activation pathways induced by CD28 costimulation. One is integrated with TCR signaling in the context of the immunological synapse and is mediated through transcriptional enhancement and the second is mediated through the induction of mRNA stability. Here, we review the immunological consequences and biochemical mechanisms associated with CD28 costimulation and discuss the major questions that need to be resolved to understand the molecular mechanisms that transduce CD28 costimulation.

AB - CD28 is recognized as the primary costimulatory molecule involved in the activation of naïve T cells. However, the biochemical signaling pathways that are activated by CD28 and how these pathways are integrated with TCR signaling are still not understood. We have recently shown that there are at least two independent activation pathways induced by CD28 costimulation. One is integrated with TCR signaling in the context of the immunological synapse and is mediated through transcriptional enhancement and the second is mediated through the induction of mRNA stability. Here, we review the immunological consequences and biochemical mechanisms associated with CD28 costimulation and discuss the major questions that need to be resolved to understand the molecular mechanisms that transduce CD28 costimulation.

KW - Antigen presentation

KW - CD28

KW - Costimulation

KW - Immunological synapse

KW - MRNA stability

KW - Signal transduction

KW - T cells

KW - Transcriptional regulation

UR - http://www.scopus.com/inward/record.url?scp=72449184637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72449184637&partnerID=8YFLogxK

U2 - 10.1007/s12026-009-8097-6

DO - 10.1007/s12026-009-8097-6

M3 - Review article

C2 - 19214786

AN - SCOPUS:72449184637

VL - 45

SP - 159

EP - 172

JO - Immunologic Research

JF - Immunologic Research

SN - 0257-277X

IS - 2-3

ER -