T1 measurements of 31P metabolites in resting and exercising human gastrocnemius/soleus muscle at 1.5 Tesla

Bradley R. Newcomer, Michael D Boska

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

This study has measured the apparent 31P T1 times at 1.5 T in human gastrocnemius/soleus muscle groups at rest, during exercise, and during recovery from a 90-sec submaximal plantar flexion exercise. T1 times were measured with a 10-sec time resolution in 11 normally active volunteers using a surface coil with a nine-point progressive saturation technique. A two- point short repetition time technique was also used. Both techniques showed similar trends in the apparent T11 times of all the 31P metabolites at rest, during exercise, and during recovery. For the nine-point progressive saturation technique, the apparent T1 of PCr and β-ATP decreased approximately 20% to a steady-state value (P = 0.027 and P = 0.004, respectively). The two-point short repetition time technique demonstrated a 10% reduction in the apparent T1 of PCr and β-ATP. Both techniques demonstrated an apparent T1 increase of 58% for inorganic phosphate at the beginning of exercise (P < 0.0001) and a return to resting value during the 90-sec submaximal isometric contraction. Neither technique showed any significant differences between resting and exercising T1 times of the α- ATP and γ-ATP resonances (P = 0.06 and P > 0.40, respectively).

Original languageEnglish (US)
Pages (from-to)486-494
Number of pages9
JournalMagnetic Resonance in Medicine
Volume41
Issue number3
DOIs
StatePublished - Apr 13 1999

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Skeletal Muscle
Exercise
Adenosine Triphosphate
Volunteers
Phosphates

Keywords

  • P MRS
  • Skeletal muscle
  • T measurements

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

T1 measurements of 31P metabolites in resting and exercising human gastrocnemius/soleus muscle at 1.5 Tesla. / Newcomer, Bradley R.; Boska, Michael D.

In: Magnetic Resonance in Medicine, Vol. 41, No. 3, 13.04.1999, p. 486-494.

Research output: Contribution to journalArticle

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