Trisomies 8 and 20 characterize a subgroup of benign fibrous lesions arising in both soft tissue and bone

Julia A. Bridge, Sarah J. Swarts, Cary Buresh, Mari Nelson, Joanne M. Degenhardt, Suzanne Spanier, Gerhard Maale, Aurelia Meloni, James C. Lynch, James R. Neff

Research output: Contribution to journalArticle

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Abstract

Trisomy 8 and trisomy 20 are nonrandom aberrations in desmoid tumors. The presence of these trisomies in related benign fibrous lesions of bone has not been previously addressed. In this study, 22 specimens from 19 patients diagnosed with desmoid tumor, desmoplastic fibroma, periosteal desmoid tumor, osteofibrous dysplasia, or fibrous dysplasia were examined by cytogenetic analysis of short-term cultures and bi-color fluorescence in situ hybridization of cytological touch preparations or paraffin-embedded tissue with centromeric probes for chromosomes 8 and 20. Trisomy 8 and trisomy 20 were detected by molecular cytogenetic methodologies in 15 specimens, including 10 primary bone lesions. Traditional cytogenetic analysis revealed trisomy 8 in two cases of osteofibrous dysplasia. Our findings demonstrate that trisomy 8 and trisomy 20 are also nonrandom aberrations in histologically similar, but clinically distinct, benign fibrous lesions of bone.

Original languageEnglish (US)
Pages (from-to)729-733
Number of pages5
JournalAmerican Journal of Pathology
Volume154
Issue number3
DOIs
StatePublished - Mar 1999

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Aggressive Fibromatosis
Bone and Bones
Cytogenetic Analysis
Desmoplastic Fibroma
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 8
Neoplasms
Trisomy
Touch
Fluorescence In Situ Hybridization
Cytogenetics
Paraffin
Color
Trisomy Chromosome 20
Trisomy Chromosome 8
Osteofibrous Dysplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Bridge, J. A., Swarts, S. J., Buresh, C., Nelson, M., Degenhardt, J. M., Spanier, S., ... Neff, J. R. (1999). Trisomies 8 and 20 characterize a subgroup of benign fibrous lesions arising in both soft tissue and bone. American Journal of Pathology, 154(3), 729-733. https://doi.org/10.1016/S0002-9440(10)65319-9

Trisomies 8 and 20 characterize a subgroup of benign fibrous lesions arising in both soft tissue and bone. / Bridge, Julia A.; Swarts, Sarah J.; Buresh, Cary; Nelson, Mari; Degenhardt, Joanne M.; Spanier, Suzanne; Maale, Gerhard; Meloni, Aurelia; Lynch, James C.; Neff, James R.

In: American Journal of Pathology, Vol. 154, No. 3, 03.1999, p. 729-733.

Research output: Contribution to journalArticle

Bridge, JA, Swarts, SJ, Buresh, C, Nelson, M, Degenhardt, JM, Spanier, S, Maale, G, Meloni, A, Lynch, JC & Neff, JR 1999, 'Trisomies 8 and 20 characterize a subgroup of benign fibrous lesions arising in both soft tissue and bone', American Journal of Pathology, vol. 154, no. 3, pp. 729-733. https://doi.org/10.1016/S0002-9440(10)65319-9
Bridge, Julia A. ; Swarts, Sarah J. ; Buresh, Cary ; Nelson, Mari ; Degenhardt, Joanne M. ; Spanier, Suzanne ; Maale, Gerhard ; Meloni, Aurelia ; Lynch, James C. ; Neff, James R. / Trisomies 8 and 20 characterize a subgroup of benign fibrous lesions arising in both soft tissue and bone. In: American Journal of Pathology. 1999 ; Vol. 154, No. 3. pp. 729-733.
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