Abstract

Purpose: To develop tooth-binding micelle formulations of triclosan for the prevention and treatment of dental caries. Methods: Alendronate (ALN) was conjugated to the chain termini of different Pluronic copolymers to confer tooth-binding ability to the micelles. Using 3 different formulation methods, Pluronics and ALN-modified Pluronics were used to prepare triclosan-loaded tooth-binding micelles. The formulation parameters were optimized for triclosan solubility, particle size, hydroxyapatite (HA) binding capability and in vitro drug release profile. The optimized formulation was tested on an in vitro biofilm model. Results: Direct dissolution was selected as the best formulation method. Triclosan-loaded tooth-binding micelles were able to inhibit initial biofilm growth of Streptococcus mutans UA159 by 6-log CFU/HA disc compared to the untreated control. These tooth-binding micelles were also able to reduce the viability of preformed biofilm by 4-log CFU/HA disc compared to the untreated control. Conclusions: Triclosan-loaded tooth-binding micelle formulations have been successfully developed and optimized in this study. These micelle formulations demonstrated promising anti-cariogenic bacteria capabilities and may find applications in the prevention and treatment of dental caries.

Original languageEnglish (US)
Pages (from-to)2356-2364
Number of pages9
JournalPharmaceutical Research
Volume27
Issue number11
DOIs
StatePublished - Nov 1 2010

Fingerprint

Triclosan
Biofilms
Micelles
Tooth
Poloxamer
Durapatite
Alendronate
Dental Caries
Streptococcus mutans
Particle Size
Solubility
Bacteria
Dissolution
Copolymers
Particle size
Growth

Keywords

  • antimicrobial
  • biofilm
  • dental caries
  • micelle
  • pluronic
  • tooth-binding
  • triclosan

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Organic Chemistry
  • Molecular Medicine
  • Pharmacology (medical)
  • Biotechnology
  • Pharmacology

Cite this

Triclosan-loaded tooth-binding micelles for prevention and treatment of dental biofilm. / Chen, Fu; Rice, Kelly C.; Liu, Xin Ming; Reinhardt, Richard A; Bayles, Kenneth W; Wang, Dong.

In: Pharmaceutical Research, Vol. 27, No. 11, 01.11.2010, p. 2356-2364.

Research output: Contribution to journalArticle

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