Tricarboxylic acid cycle-dependent synthesis of Staphylococcus aureus type 5 and 8 capsular polysaccharides

Marat R. Sadykov, Theodoric A. Mattes, Thanh T. Luong, Yefei Zhu, Shandra R. Day, Costi D. Sifri, Chia Y. Lee, Greg A Somerville

Research output: Contribution to journalArticle

35 Scopus citations


Staphylococcus aureus capsule synthesis requires the precursor N-acetyl-glucosamine; however, capsule is synthesized during post-exponential growth when the availability of N-acetyl-glucosamine is limited. Capsule biosynthesis also requires aerobic respiration, leading us to hypothesize that capsule synthesis requires tricarboxylic acid cycle intermediates. Consistent with this hypothesis, S. aureus tricarboxylic acid cycle mutants fail to make capsule.

Original languageEnglish (US)
Pages (from-to)1459-1462
Number of pages4
JournalJournal of bacteriology
Issue number5
StatePublished - Mar 1 2010


ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this