Tricarboxylic acid cycle-dependent synthesis of Staphylococcus aureus type 5 and 8 capsular polysaccharides

Marat R. Sadykov, Theodoric A. Mattes, Thanh T. Luong, Yefei Zhu, Shandra R. Day, Costi D. Sifri, Chia Y. Lee, Greg A Somerville

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Staphylococcus aureus capsule synthesis requires the precursor N-acetyl-glucosamine; however, capsule is synthesized during post-exponential growth when the availability of N-acetyl-glucosamine is limited. Capsule biosynthesis also requires aerobic respiration, leading us to hypothesize that capsule synthesis requires tricarboxylic acid cycle intermediates. Consistent with this hypothesis, S. aureus tricarboxylic acid cycle mutants fail to make capsule.

Original languageEnglish (US)
Pages (from-to)1459-1462
Number of pages4
JournalJournal of bacteriology
Volume192
Issue number5
DOIs
StatePublished - Mar 1 2010

Fingerprint

Citric Acid Cycle
Capsules
Glucosamine
Staphylococcus aureus
Respiration
Staphylococcus aureus capsular polysaccharide type 5
Growth

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

Tricarboxylic acid cycle-dependent synthesis of Staphylococcus aureus type 5 and 8 capsular polysaccharides. / Sadykov, Marat R.; Mattes, Theodoric A.; Luong, Thanh T.; Zhu, Yefei; Day, Shandra R.; Sifri, Costi D.; Lee, Chia Y.; Somerville, Greg A.

In: Journal of bacteriology, Vol. 192, No. 5, 01.03.2010, p. 1459-1462.

Research output: Contribution to journalArticle

Sadykov, Marat R. ; Mattes, Theodoric A. ; Luong, Thanh T. ; Zhu, Yefei ; Day, Shandra R. ; Sifri, Costi D. ; Lee, Chia Y. ; Somerville, Greg A. / Tricarboxylic acid cycle-dependent synthesis of Staphylococcus aureus type 5 and 8 capsular polysaccharides. In: Journal of bacteriology. 2010 ; Vol. 192, No. 5. pp. 1459-1462.
@article{c2107cadcaa24c3b9cbdfc43c5376f68,
title = "Tricarboxylic acid cycle-dependent synthesis of Staphylococcus aureus type 5 and 8 capsular polysaccharides",
abstract = "Staphylococcus aureus capsule synthesis requires the precursor N-acetyl-glucosamine; however, capsule is synthesized during post-exponential growth when the availability of N-acetyl-glucosamine is limited. Capsule biosynthesis also requires aerobic respiration, leading us to hypothesize that capsule synthesis requires tricarboxylic acid cycle intermediates. Consistent with this hypothesis, S. aureus tricarboxylic acid cycle mutants fail to make capsule.",
author = "Sadykov, {Marat R.} and Mattes, {Theodoric A.} and Luong, {Thanh T.} and Yefei Zhu and Day, {Shandra R.} and Sifri, {Costi D.} and Lee, {Chia Y.} and Somerville, {Greg A}",
year = "2010",
month = "3",
day = "1",
doi = "10.1128/JB.01377-09",
language = "English (US)",
volume = "192",
pages = "1459--1462",
journal = "Journal of Bacteriology",
issn = "0021-9193",
publisher = "American Society for Microbiology",
number = "5",

}

TY - JOUR

T1 - Tricarboxylic acid cycle-dependent synthesis of Staphylococcus aureus type 5 and 8 capsular polysaccharides

AU - Sadykov, Marat R.

AU - Mattes, Theodoric A.

AU - Luong, Thanh T.

AU - Zhu, Yefei

AU - Day, Shandra R.

AU - Sifri, Costi D.

AU - Lee, Chia Y.

AU - Somerville, Greg A

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Staphylococcus aureus capsule synthesis requires the precursor N-acetyl-glucosamine; however, capsule is synthesized during post-exponential growth when the availability of N-acetyl-glucosamine is limited. Capsule biosynthesis also requires aerobic respiration, leading us to hypothesize that capsule synthesis requires tricarboxylic acid cycle intermediates. Consistent with this hypothesis, S. aureus tricarboxylic acid cycle mutants fail to make capsule.

AB - Staphylococcus aureus capsule synthesis requires the precursor N-acetyl-glucosamine; however, capsule is synthesized during post-exponential growth when the availability of N-acetyl-glucosamine is limited. Capsule biosynthesis also requires aerobic respiration, leading us to hypothesize that capsule synthesis requires tricarboxylic acid cycle intermediates. Consistent with this hypothesis, S. aureus tricarboxylic acid cycle mutants fail to make capsule.

UR - http://www.scopus.com/inward/record.url?scp=77749279738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77749279738&partnerID=8YFLogxK

U2 - 10.1128/JB.01377-09

DO - 10.1128/JB.01377-09

M3 - Article

C2 - 20061474

AN - SCOPUS:77749279738

VL - 192

SP - 1459

EP - 1462

JO - Journal of Bacteriology

JF - Journal of Bacteriology

SN - 0021-9193

IS - 5

ER -