Trends in bone marrow sampling and core biopsy specimen adequacy in the United States and Canada: A multicenter study

Mihai Merzianu, Adrienne Groman, Alan Hutson, Claudiu Cotta, Russell K. Brynes, Attilio Orazi, Vishnu Reddy, Julie Teruya-Feldstein, Ramila Amre, Manjula Balasubramanian, Guilherme Brandao, Sindhu Cherian, Elizabeth Courville, David Czuchlewski, Guang Fan, David Grier, Daniela Hoehn, Kedar V. Inamdar, Ridas Juskevicius, Prabhjot KaurJohn Lazarchick, Michael R. Lewis, Rodney R. Miles, Jerome B. Myers, Michel R. Nasr, Hina N. Qureishi, Horatiu Olteanu, Valentin G. Robu, Gratian Salaru, Neerja Vajpayee, Jeffrey Vos, Ling Zhang, Shanxiang Zhang, Le Aye, Elisa Brega, James E. Coad, John Grantham, Sinisa Ivelja, Robert McKenna, Kieran Sultan, Gregory Wilding, Robert Hutchison, Loann Peterson, Richard T. Cheney

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Objectives: To assess bone marrow (BM) sampling in academic medical centers. Methods: Data from 6,374 BM samples obtained in 32 centers in 2001 and 2011, including core length (CL), were analyzed. Results: BM included a biopsy (BMB; 93%) specimen, aspirate (BMA; 92%) specimen, or both (83%). The median (SD) CL was 12 (8.5) mm, and evaluable marrow was 9 (7.6) mm. Tissue contraction due to processing was 15%. BMB specimens were longer in adults younger than 60 years, men, and bilateral, staging, and baseline samples. Only 4% of BMB and 2% of BMB/BMA samples were deemed inadequate for diagnosis. BM for plasma cell dyscrasias, nonphysician operators, and ancillary studies usage increased, while bilateral sampling decreased over the decade. BM-related quality assurance programs are infrequent. Conclusions: CL is shorter than recommended and varies with patient age and sex, clinical circumstances, and center experience. While pathologists render diagnoses on most cases irrespective of CL, BMB yield improvement is desirable.

Original languageEnglish (US)
Pages (from-to)393-405
Number of pages13
JournalAmerican journal of clinical pathology
Volume150
Issue number5
DOIs
StatePublished - Oct 1 2018

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Keywords

  • Bone marrow adequacy
  • Bone marrow biopsy
  • Bone marrow biopsy indications
  • Bone marrow quality
  • Core biopsy length

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Merzianu, M., Groman, A., Hutson, A., Cotta, C., Brynes, R. K., Orazi, A., Reddy, V., Teruya-Feldstein, J., Amre, R., Balasubramanian, M., Brandao, G., Cherian, S., Courville, E., Czuchlewski, D., Fan, G., Grier, D., Hoehn, D., Inamdar, K. V., Juskevicius, R., ... Cheney, R. T. (2018). Trends in bone marrow sampling and core biopsy specimen adequacy in the United States and Canada: A multicenter study. American journal of clinical pathology, 150(5), 393-405. https://doi.org/10.1093/ajcp/aqy066