Treatment, outcomes, costs, and quality of life of women and men with acute coronary syndromes who have undergone Percutaneous coronary intervention: Results from the Antiplatelet Therapy Observational Registry

Ameet Bakhai, Jean Ferrières, Stefan James, Andres Iñiguez, Attila Mohácsi, Gregory Pavlides, Mark Belger, Krisi Norrbacka, Magali Sartral

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Treatment, outcomes, costs, and quality of life after percutaneous coronary intervention (PCI) were compared between women and men with acute coronary syndromes (ACS) using data from the Antiplatelet Therapy Observational Registry (APTOR). Methods: Fourteen European countries participated in this noninterventional, prospective, observational cohort registry, which enrolled patients with ACS who underwent PCI from 2007 to 2009. The 12-month outcomes included bleeding, cardiovascular events, and mortality. Quality of life was measured using the EQ-5D™ (EuroQol Group) health index and the visual analog scale. Results: The APTOR registry included 4546 patients, of whom 1047 (23%) were women and 3499 (77%) were men. The women were older (mean age, 67 vs 61 years) and had higher rates of diabetes mellitus and hypertension. A greater proportion of the men were smokers (40% vs 30%). Approximately 70% of the patients underwent PCI on the day of the qualifying ACS event. Women and men received similar medications at the time of PCI, hospital discharge, and 12-month follow-up visit. Bleeding, cardiovascular events, and mortality occurred at higher rates in women than in men, but the differences were not statistically significant. At 12 months post-PCI, women reported lower quality-of-life scores on the EQ-5D™ health index and the visual analog scale than did men. The mean total cost of care was £6252 (€7189) for women and £5841 (€6717) for men; the differences may be driven by resource use after discharge from the hospital. Conclusion: Women with ACS tended to be older and had more comorbidities than men, but both sexes experienced similar outcomes after 1 year. This study indicated no differences in treatment between sexes.

Original languageEnglish (US)
Pages (from-to)100-107
Number of pages8
JournalPostgraduate Medicine
Volume125
Issue number2
DOIs
StatePublished - Mar 1 2013

Fingerprint

Percutaneous Coronary Intervention
Acute Coronary Syndrome
Health Care Costs
Registries
Quality of Life
Therapeutics
Visual Analog Scale
Hemorrhage
Mortality
Health
Comorbidity
Diabetes Mellitus
Hypertension
Costs and Cost Analysis

Keywords

  • Acute coronary syndromes
  • Catheter-based coronary interventions
  • Catheterization
  • Coronary disease
  • Epidemiology
  • Secondary prevention
  • Sex
  • Stents

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Treatment, outcomes, costs, and quality of life of women and men with acute coronary syndromes who have undergone Percutaneous coronary intervention : Results from the Antiplatelet Therapy Observational Registry. / Bakhai, Ameet; Ferrières, Jean; James, Stefan; Iñiguez, Andres; Mohácsi, Attila; Pavlides, Gregory; Belger, Mark; Norrbacka, Krisi; Sartral, Magali.

In: Postgraduate Medicine, Vol. 125, No. 2, 01.03.2013, p. 100-107.

Research output: Contribution to journalArticle

Bakhai, Ameet ; Ferrières, Jean ; James, Stefan ; Iñiguez, Andres ; Mohácsi, Attila ; Pavlides, Gregory ; Belger, Mark ; Norrbacka, Krisi ; Sartral, Magali. / Treatment, outcomes, costs, and quality of life of women and men with acute coronary syndromes who have undergone Percutaneous coronary intervention : Results from the Antiplatelet Therapy Observational Registry. In: Postgraduate Medicine. 2013 ; Vol. 125, No. 2. pp. 100-107.
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T1 - Treatment, outcomes, costs, and quality of life of women and men with acute coronary syndromes who have undergone Percutaneous coronary intervention

T2 - Results from the Antiplatelet Therapy Observational Registry

AU - Bakhai, Ameet

AU - Ferrières, Jean

AU - James, Stefan

AU - Iñiguez, Andres

AU - Mohácsi, Attila

AU - Pavlides, Gregory

AU - Belger, Mark

AU - Norrbacka, Krisi

AU - Sartral, Magali

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N2 - Background: Treatment, outcomes, costs, and quality of life after percutaneous coronary intervention (PCI) were compared between women and men with acute coronary syndromes (ACS) using data from the Antiplatelet Therapy Observational Registry (APTOR). Methods: Fourteen European countries participated in this noninterventional, prospective, observational cohort registry, which enrolled patients with ACS who underwent PCI from 2007 to 2009. The 12-month outcomes included bleeding, cardiovascular events, and mortality. Quality of life was measured using the EQ-5D™ (EuroQol Group) health index and the visual analog scale. Results: The APTOR registry included 4546 patients, of whom 1047 (23%) were women and 3499 (77%) were men. The women were older (mean age, 67 vs 61 years) and had higher rates of diabetes mellitus and hypertension. A greater proportion of the men were smokers (40% vs 30%). Approximately 70% of the patients underwent PCI on the day of the qualifying ACS event. Women and men received similar medications at the time of PCI, hospital discharge, and 12-month follow-up visit. Bleeding, cardiovascular events, and mortality occurred at higher rates in women than in men, but the differences were not statistically significant. At 12 months post-PCI, women reported lower quality-of-life scores on the EQ-5D™ health index and the visual analog scale than did men. The mean total cost of care was £6252 (€7189) for women and £5841 (€6717) for men; the differences may be driven by resource use after discharge from the hospital. Conclusion: Women with ACS tended to be older and had more comorbidities than men, but both sexes experienced similar outcomes after 1 year. This study indicated no differences in treatment between sexes.

AB - Background: Treatment, outcomes, costs, and quality of life after percutaneous coronary intervention (PCI) were compared between women and men with acute coronary syndromes (ACS) using data from the Antiplatelet Therapy Observational Registry (APTOR). Methods: Fourteen European countries participated in this noninterventional, prospective, observational cohort registry, which enrolled patients with ACS who underwent PCI from 2007 to 2009. The 12-month outcomes included bleeding, cardiovascular events, and mortality. Quality of life was measured using the EQ-5D™ (EuroQol Group) health index and the visual analog scale. Results: The APTOR registry included 4546 patients, of whom 1047 (23%) were women and 3499 (77%) were men. The women were older (mean age, 67 vs 61 years) and had higher rates of diabetes mellitus and hypertension. A greater proportion of the men were smokers (40% vs 30%). Approximately 70% of the patients underwent PCI on the day of the qualifying ACS event. Women and men received similar medications at the time of PCI, hospital discharge, and 12-month follow-up visit. Bleeding, cardiovascular events, and mortality occurred at higher rates in women than in men, but the differences were not statistically significant. At 12 months post-PCI, women reported lower quality-of-life scores on the EQ-5D™ health index and the visual analog scale than did men. The mean total cost of care was £6252 (€7189) for women and £5841 (€6717) for men; the differences may be driven by resource use after discharge from the hospital. Conclusion: Women with ACS tended to be older and had more comorbidities than men, but both sexes experienced similar outcomes after 1 year. This study indicated no differences in treatment between sexes.

KW - Acute coronary syndromes

KW - Catheter-based coronary interventions

KW - Catheterization

KW - Coronary disease

KW - Epidemiology

KW - Secondary prevention

KW - Sex

KW - Stents

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