Treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation

Naoya Kobayashi, Masahiro Ito, Junta Nakamura, Jin Cai, James M Hammel, Ira J. Fox

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Abstract

Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhosis (LC) has not been adequately studied. In order to address this issue, HTx was performed in rats following induction of stable LC using phenobarbital (PhB) and carbon tetrachloride (CCl4). Intrasplenic transplantation of 50 x 106 primary hepatocytes could significantly improve liver functions and prolong the survival of rats with irreversible, decompensated LC.

Original languageEnglish (US)
Pages (from-to)671-673
Number of pages3
JournalCell Transplantation
Volume9
Issue number5
DOIs
Publication statusPublished - Jan 1 2000

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Keywords

  • Carbon tetrachloride
  • Hepatocyte transplantation
  • Liver cirrhosis
  • Phenobarbital

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

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