Treatment of breast cancer with oral four‐drug chemotherapy

John F. Foley, Margaret Anne Kessinger, Henry M. Lemon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Seventy patients with advanced metastatic breast cancer were treated with an oral drug regime of prednisone, cytomel, cytoxan, and methotrexate. One half of the cases (50%) had a response. There were complete remissions in 7%, partial remissions in 27%, and arrests in 16%. The median duration of remissions was 8+ months. There was no significant difference in response between patients with predominant visceral or bone disease nor between pre‐ and post‐menopausal women. One third of non‐hormonally responsive patients responded to this treatment. Side effects consisted predominantly of glucocorticoid change, including cushinoid facies and weight gain. The program was relatively bone marrow sparing. This drug regime is very convenient and safe to give on an outpatient basis.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalJournal of Surgical Oncology
Volume14
Issue number1
DOIs
StatePublished - Jan 1 1980

Fingerprint

Mouth Neoplasms
Breast Neoplasms
Drug Therapy
Bone Diseases
Triiodothyronine
Prednisone
Methotrexate
Pharmaceutical Preparations
Cyclophosphamide
Glucocorticoids
Weight Gain
Outpatients
Therapeutics
Bone Marrow

Keywords

  • breast cancer
  • oral chemotherapy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Treatment of breast cancer with oral four‐drug chemotherapy. / Foley, John F.; Kessinger, Margaret Anne; Lemon, Henry M.

In: Journal of Surgical Oncology, Vol. 14, No. 1, 01.01.1980, p. 67-72.

Research output: Contribution to journalArticle

Foley, John F. ; Kessinger, Margaret Anne ; Lemon, Henry M. / Treatment of breast cancer with oral four‐drug chemotherapy. In: Journal of Surgical Oncology. 1980 ; Vol. 14, No. 1. pp. 67-72.
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