Treatment of adult acute lymphoblastic leukemia with cytosine arabinoside, vincristine, and prednisone

R. D. Gingrich, James Olen Armitage, C. P. Burns

Research output: Contribution to journalArticle

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Abstract

Thirteen adults with acute lymphoblastic leukemia were entered into a protocol in which cytosine arabinoside infusion was added to vincristine and prednisone as remission induction and periodic intensification therapy. Central nervous system prophylaxis consisting of cranial irradiation and intrathecal methotrexate was given, and all patients received continuous oral 6-mercaptopurine and methotrexate as maintenance treatment. Myelotoxicity was severe during induction, with prolonged granulocyte and platelet count nadirs noted. Nine of 13 patients (69%) obtained a complete remission and one (8%) obtained a partial remission. The median duration of complete remission was 38.1 weeks. It was concluded that cytosine arabinoside in combination with vincristine and prednisone is an effective but toxic antileukemic regimen which did not produce a major improvement in remission duration.

Original languageEnglish (US)
Pages (from-to)1389-1391
Number of pages3
JournalCancer Treatment Reports
Volume62
Issue number9
StatePublished - Dec 1 1978

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Cytarabine
Vincristine
Prednisone
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methotrexate
Cranial Irradiation
Remission Induction
6-Mercaptopurine
Poisons
Platelet Count
Granulocytes
Central Nervous System
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Treatment of adult acute lymphoblastic leukemia with cytosine arabinoside, vincristine, and prednisone. / Gingrich, R. D.; Armitage, James Olen; Burns, C. P.

In: Cancer Treatment Reports, Vol. 62, No. 9, 01.12.1978, p. 1389-1391.

Research output: Contribution to journalArticle

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