Transmission of monkeypox among persons exposed to infected prairie dogs in Indiana in 2003

James C. Kile, Aaron T. Fleischauer, Bradley Beard, Matthew J. Kuehnert, Richard S. Kanwal, Pamela Pontones, Hans J. Messersmith, Robert Teclaw, Kevin L. Karem, Zachary H. Braden, Inger Damon, Ali S. Khan, Marc Fischer

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objective: To describe a cluster of human monkeypox cases associated with exposure to ill prairie dogs in a home child care. Design, Setting, Participants: We identified all persons exposed to 2 pet prairie dogs in County A, Indiana; performed active surveillance for symptomatic monkeypox infection; and evaluated the types of exposure that may have resulted in infection. For children who attended the child care where the animals were housed, we also measured the rate of seroconversion to monkeypox virus. Main Outcome Measures: Nine (13%) of 70 persons exposed to the prairie dogs reported signs and symptoms of monkeypox. Two (40%) of 5 symptomatic child care attendees reported direct contact with the prairie dogs. Two (13%) of 15 child care attendees evaluated tested positive for IgM antibodies against orthopoxvirus; both reported symptoms consistent with monkeypox. Results: The risk of symptomatic infection correlated with the time and intensity of animal exposure, which was 100% (4/4) among family members with extensive direct contact, 19% (5/26) among the veterinarian and nonfamily child care attendees with moderate exposure, and 0% (0/40) among school children with limited exposure (P<.01). Conclusions: Monkeypox virus was transmitted from ill prairie dogs in a child care and veterinary facilities. The risk of symptomatic infection correlated with the amount of exposure to the prairie dogs. Although most cases of human monkeypox were associated with direct animal contact, other routes of transmission cannot be excluded.

Original languageEnglish (US)
Pages (from-to)1022-1025
Number of pages4
JournalArchives of Pediatrics and Adolescent Medicine
Volume159
Issue number11
DOIs
StatePublished - Nov 1 2005

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Monkeypox
Sciuridae
Child Care
Monkeypox virus
Infection
Orthopoxvirus
Veterinarians
Pets
Home Care Services
Signs and Symptoms
Immunoglobulin M
Outcome Assessment (Health Care)
Antibodies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Kile, J. C., Fleischauer, A. T., Beard, B., Kuehnert, M. J., Kanwal, R. S., Pontones, P., ... Fischer, M. (2005). Transmission of monkeypox among persons exposed to infected prairie dogs in Indiana in 2003. Archives of Pediatrics and Adolescent Medicine, 159(11), 1022-1025. https://doi.org/10.1001/archpedi.159.11.1022

Transmission of monkeypox among persons exposed to infected prairie dogs in Indiana in 2003. / Kile, James C.; Fleischauer, Aaron T.; Beard, Bradley; Kuehnert, Matthew J.; Kanwal, Richard S.; Pontones, Pamela; Messersmith, Hans J.; Teclaw, Robert; Karem, Kevin L.; Braden, Zachary H.; Damon, Inger; Khan, Ali S.; Fischer, Marc.

In: Archives of Pediatrics and Adolescent Medicine, Vol. 159, No. 11, 01.11.2005, p. 1022-1025.

Research output: Contribution to journalArticle

Kile, JC, Fleischauer, AT, Beard, B, Kuehnert, MJ, Kanwal, RS, Pontones, P, Messersmith, HJ, Teclaw, R, Karem, KL, Braden, ZH, Damon, I, Khan, AS & Fischer, M 2005, 'Transmission of monkeypox among persons exposed to infected prairie dogs in Indiana in 2003', Archives of Pediatrics and Adolescent Medicine, vol. 159, no. 11, pp. 1022-1025. https://doi.org/10.1001/archpedi.159.11.1022
Kile, James C. ; Fleischauer, Aaron T. ; Beard, Bradley ; Kuehnert, Matthew J. ; Kanwal, Richard S. ; Pontones, Pamela ; Messersmith, Hans J. ; Teclaw, Robert ; Karem, Kevin L. ; Braden, Zachary H. ; Damon, Inger ; Khan, Ali S. ; Fischer, Marc. / Transmission of monkeypox among persons exposed to infected prairie dogs in Indiana in 2003. In: Archives of Pediatrics and Adolescent Medicine. 2005 ; Vol. 159, No. 11. pp. 1022-1025.
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abstract = "Objective: To describe a cluster of human monkeypox cases associated with exposure to ill prairie dogs in a home child care. Design, Setting, Participants: We identified all persons exposed to 2 pet prairie dogs in County A, Indiana; performed active surveillance for symptomatic monkeypox infection; and evaluated the types of exposure that may have resulted in infection. For children who attended the child care where the animals were housed, we also measured the rate of seroconversion to monkeypox virus. Main Outcome Measures: Nine (13{\%}) of 70 persons exposed to the prairie dogs reported signs and symptoms of monkeypox. Two (40{\%}) of 5 symptomatic child care attendees reported direct contact with the prairie dogs. Two (13{\%}) of 15 child care attendees evaluated tested positive for IgM antibodies against orthopoxvirus; both reported symptoms consistent with monkeypox. Results: The risk of symptomatic infection correlated with the time and intensity of animal exposure, which was 100{\%} (4/4) among family members with extensive direct contact, 19{\%} (5/26) among the veterinarian and nonfamily child care attendees with moderate exposure, and 0{\%} (0/40) among school children with limited exposure (P<.01). Conclusions: Monkeypox virus was transmitted from ill prairie dogs in a child care and veterinary facilities. The risk of symptomatic infection correlated with the amount of exposure to the prairie dogs. Although most cases of human monkeypox were associated with direct animal contact, other routes of transmission cannot be excluded.",
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