Transmission of maternal muscle-specific tyrosine kinase (MuSK) to offspring

Report of two cases

Earnest L. Murray, Sachin Kedar, V. V. Vedanarayanan

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Familial occurrence of myasthenia gravis is uncommon and reports of maternal transmission of muscle-specific tyrosine kinase (MuSK) antibody myasthenia are rarer still. We report two families with maternal transmission of MuSK antibody myasthenia gravis to the offspring by different mechanisms. The first family demonstrates transmission genetic susceptibility of inheriting myasthenia gravis from MuSK antibodies, whereas the second one demonstrates transplacental transmission of MuSK antibodies at birth.

Original languageEnglish (US)
Pages (from-to)76-79
Number of pages4
JournalJournal of Clinical Neuromuscular Disease
Volume12
Issue number2
DOIs
StatePublished - Dec 1 2010

Fingerprint

Protein-Tyrosine Kinases
Myasthenia Gravis
Mothers
Muscles
Antibodies
Genetic Predisposition to Disease
Parturition

Keywords

  • Inherited musk antibodies
  • Transient neonatal musk antibodies
  • Transmission of MuSK antibodies

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Transmission of maternal muscle-specific tyrosine kinase (MuSK) to offspring : Report of two cases. / Murray, Earnest L.; Kedar, Sachin; Vedanarayanan, V. V.

In: Journal of Clinical Neuromuscular Disease, Vol. 12, No. 2, 01.12.2010, p. 76-79.

Research output: Contribution to journalReview article

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