Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma

Matthew R. Mendlick, Marilu Nelson, Diane Pickering, Sonny L. Johansson, Thomas A. Seemayer, James R. Neff, Gerardo Vergara, Howard Rosenthal, Julia A. Bridge

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

The cytogenetic findings for two epithelioid hemangioendotheliomas are reported. An identical chromosomal translocation involving chromosomes 1 and 3 [t(1;3)(p36.3;q25)] was detected in both cases of epithelioid hemangioendothelioma, possibly representing a characteristic rearrangement for this histopathologic entity. The presence of clonal karyotypic abnormalities supports a neoplastic origin for the epithelioid variant of hemangioendothelioma. Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process.

Original languageEnglish (US)
Pages (from-to)684-687
Number of pages4
JournalAmerican Journal of Surgical Pathology
Volume25
Issue number5
DOIs
StatePublished - May 21 2001

Fingerprint

Epithelioid Hemangioendothelioma
Neoplastic Processes
Genetic Translocation
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 1
Cytogenetics
Genes

Keywords

  • Chromosome
  • Cytogenetics
  • Hemangioendothelioma
  • Karyotype
  • Vascular tumors

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Mendlick, M. R., Nelson, M., Pickering, D., Johansson, S. L., Seemayer, T. A., Neff, J. R., ... Bridge, J. A. (2001). Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma. American Journal of Surgical Pathology, 25(5), 684-687. https://doi.org/10.1097/00000478-200105000-00019

Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma. / Mendlick, Matthew R.; Nelson, Marilu; Pickering, Diane; Johansson, Sonny L.; Seemayer, Thomas A.; Neff, James R.; Vergara, Gerardo; Rosenthal, Howard; Bridge, Julia A.

In: American Journal of Surgical Pathology, Vol. 25, No. 5, 21.05.2001, p. 684-687.

Research output: Contribution to journalArticle

Mendlick, MR, Nelson, M, Pickering, D, Johansson, SL, Seemayer, TA, Neff, JR, Vergara, G, Rosenthal, H & Bridge, JA 2001, 'Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma', American Journal of Surgical Pathology, vol. 25, no. 5, pp. 684-687. https://doi.org/10.1097/00000478-200105000-00019
Mendlick, Matthew R. ; Nelson, Marilu ; Pickering, Diane ; Johansson, Sonny L. ; Seemayer, Thomas A. ; Neff, James R. ; Vergara, Gerardo ; Rosenthal, Howard ; Bridge, Julia A. / Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma. In: American Journal of Surgical Pathology. 2001 ; Vol. 25, No. 5. pp. 684-687.
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