Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia

Muhamed Baljevic, Omar Abdel-Wahab, Raajit Rampal, Peter G. Maslak, Virginia M. Klimek, Todd L. Rosenblat, Dan Douer, Ross L. Levine, Martin S. Tallman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Translocation t(11;17) is a well-recognized variant of acute promyelocytic leukemia (APL) and has also been identified in patients with mixed-lineage leukemia (MLL) non-APL acute myeloid leukemia. Here, we describe two patients bearing translocation t(11;17) presenting with a clinical diagnosis of de novo myelodysplastic syndrome (MDS): the first with sole karyotypic abnormality 46,XY,t(11;17)(p11.2; p13) and the second where it represented one of the two karyotypic abnormalities 46,XX,del(5)(q13q33)46,XX,del(5)(q13q33),t(11;17) (q24;q23). Molecular characterization of both cases failed to identify fusion transcripts involving MLL or PLZF-RARA and no collaborating somatic mutations commonly found among MDS patients were seen in either case, suggesting the presence of an as yet unidentified oncogenic fusion protein.

Original languageEnglish (US)
Pages (from-to)48-54
Number of pages7
JournalActa Haematologica
Volume129
Issue number1
DOIs
StatePublished - Jan 1 2013

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Acute Promyelocytic Leukemia
Myelodysplastic Syndromes
Biphenotypic Acute Leukemia
Acute Myeloid Leukemia
Leukemia
Mutation
Proteins

Keywords

  • Myelodysplastic syndrome
  • Promyelocytic leukemia
  • Translocation t(11;17)

ASJC Scopus subject areas

  • Hematology

Cite this

Baljevic, M., Abdel-Wahab, O., Rampal, R., Maslak, P. G., Klimek, V. M., Rosenblat, T. L., ... Tallman, M. S. (2013). Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia. Acta Haematologica, 129(1), 48-54. https://doi.org/10.1159/000342493

Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia. / Baljevic, Muhamed; Abdel-Wahab, Omar; Rampal, Raajit; Maslak, Peter G.; Klimek, Virginia M.; Rosenblat, Todd L.; Douer, Dan; Levine, Ross L.; Tallman, Martin S.

In: Acta Haematologica, Vol. 129, No. 1, 01.01.2013, p. 48-54.

Research output: Contribution to journalArticle

Baljevic, M, Abdel-Wahab, O, Rampal, R, Maslak, PG, Klimek, VM, Rosenblat, TL, Douer, D, Levine, RL & Tallman, MS 2013, 'Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia', Acta Haematologica, vol. 129, no. 1, pp. 48-54. https://doi.org/10.1159/000342493
Baljevic, Muhamed ; Abdel-Wahab, Omar ; Rampal, Raajit ; Maslak, Peter G. ; Klimek, Virginia M. ; Rosenblat, Todd L. ; Douer, Dan ; Levine, Ross L. ; Tallman, Martin S. / Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia. In: Acta Haematologica. 2013 ; Vol. 129, No. 1. pp. 48-54.
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