Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling: Cardiac metalloproteinase actions (carMA) postulates

Rugmani Padmanabhan Iyer, Lisandra E. De Castro Brás, Yu Fang Jin, Merry L. Lindsey

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

The first matrix metalloproteinase (MMP) was described in 1962; and since the 1990s, cardiovascular research has focused on understanding how MMPs regulate many aspects of cardiovascular pathology from atherosclerosis formation to myocardial infarction and stroke. Although much information has been gleaned by these past reports, to a large degree MMP cardiovascular biology remains observational, with few studies homing in on cause and effect relationships. KochÊs postulates were first developed in the 19th century as a way to establish microorganism function and were modified in the 20th century to include methods to establish molecular causality. In this review, we outline the concept for establishing a similar approach to determine causality in terms of MMP functions. We use left ventricular remodeling postmyocardial infarction as an example, but this approach will have broad applicability across both the cardiovascular and the MMP fields.

Original languageEnglish (US)
Pages (from-to)860-871
Number of pages12
JournalCirculation Research
Volume114
Issue number5
DOIs
StatePublished - Feb 28 2014

Fingerprint

Metalloproteases
Matrix Metalloproteinases
Infarction
Causality
Ventricular Remodeling
Atherosclerosis
Stroke
Myocardial Infarction
Pathology
Research

Keywords

  • Extracellular matrix
  • fibrosis
  • inflammation
  • matrix metalloproteinases
  • proteomics
  • ventricular remodeling

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling : Cardiac metalloproteinase actions (carMA) postulates. / Iyer, Rugmani Padmanabhan; De Castro Brás, Lisandra E.; Jin, Yu Fang; Lindsey, Merry L.

In: Circulation Research, Vol. 114, No. 5, 28.02.2014, p. 860-871.

Research output: Contribution to journalReview article

@article{fab1cd1ce1f049b9951772b8dc3d43b8,
title = "Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling: Cardiac metalloproteinase actions (carMA) postulates",
abstract = "The first matrix metalloproteinase (MMP) was described in 1962; and since the 1990s, cardiovascular research has focused on understanding how MMPs regulate many aspects of cardiovascular pathology from atherosclerosis formation to myocardial infarction and stroke. Although much information has been gleaned by these past reports, to a large degree MMP cardiovascular biology remains observational, with few studies homing in on cause and effect relationships. Koch{\^E}s postulates were first developed in the 19th century as a way to establish microorganism function and were modified in the 20th century to include methods to establish molecular causality. In this review, we outline the concept for establishing a similar approach to determine causality in terms of MMP functions. We use left ventricular remodeling postmyocardial infarction as an example, but this approach will have broad applicability across both the cardiovascular and the MMP fields.",
keywords = "Extracellular matrix, fibrosis, inflammation, matrix metalloproteinases, proteomics, ventricular remodeling",
author = "Iyer, {Rugmani Padmanabhan} and {De Castro Br{\'a}s}, {Lisandra E.} and Jin, {Yu Fang} and Lindsey, {Merry L.}",
year = "2014",
month = "2",
day = "28",
doi = "10.1161/CIRCRESAHA.114.301673",
language = "English (US)",
volume = "114",
pages = "860--871",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling

T2 - Cardiac metalloproteinase actions (carMA) postulates

AU - Iyer, Rugmani Padmanabhan

AU - De Castro Brás, Lisandra E.

AU - Jin, Yu Fang

AU - Lindsey, Merry L.

PY - 2014/2/28

Y1 - 2014/2/28

N2 - The first matrix metalloproteinase (MMP) was described in 1962; and since the 1990s, cardiovascular research has focused on understanding how MMPs regulate many aspects of cardiovascular pathology from atherosclerosis formation to myocardial infarction and stroke. Although much information has been gleaned by these past reports, to a large degree MMP cardiovascular biology remains observational, with few studies homing in on cause and effect relationships. KochÊs postulates were first developed in the 19th century as a way to establish microorganism function and were modified in the 20th century to include methods to establish molecular causality. In this review, we outline the concept for establishing a similar approach to determine causality in terms of MMP functions. We use left ventricular remodeling postmyocardial infarction as an example, but this approach will have broad applicability across both the cardiovascular and the MMP fields.

AB - The first matrix metalloproteinase (MMP) was described in 1962; and since the 1990s, cardiovascular research has focused on understanding how MMPs regulate many aspects of cardiovascular pathology from atherosclerosis formation to myocardial infarction and stroke. Although much information has been gleaned by these past reports, to a large degree MMP cardiovascular biology remains observational, with few studies homing in on cause and effect relationships. KochÊs postulates were first developed in the 19th century as a way to establish microorganism function and were modified in the 20th century to include methods to establish molecular causality. In this review, we outline the concept for establishing a similar approach to determine causality in terms of MMP functions. We use left ventricular remodeling postmyocardial infarction as an example, but this approach will have broad applicability across both the cardiovascular and the MMP fields.

KW - Extracellular matrix

KW - fibrosis

KW - inflammation

KW - matrix metalloproteinases

KW - proteomics

KW - ventricular remodeling

UR - http://www.scopus.com/inward/record.url?scp=84896780190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896780190&partnerID=8YFLogxK

U2 - 10.1161/CIRCRESAHA.114.301673

DO - 10.1161/CIRCRESAHA.114.301673

M3 - Review article

C2 - 24577966

AN - SCOPUS:84896780190

VL - 114

SP - 860

EP - 871

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 5

ER -