Transgenic/knockout mice - tools to study autoimmunity

Regula Mueller, Nora Sarvetnick

Research output: Contribution to journalArticle

7 Scopus citations


Transgenic and knockout mice have been valuable tools for clarifying the roles of individual cell types and effector molecules in the pathogenesis of autoimmunity. During the past year, new strains have been added to the large array of transgenic mice, with broad or tissue-specific expression of transgene products. These laboratory models, as well as knockout mice lacking genes for a particular molecule, have greatly enhanced our understanding of autoimmune disease.

Original languageEnglish (US)
Pages (from-to)799-803
Number of pages5
JournalCurrent Opinion in Immunology
Issue number6
StatePublished - Dec 1995


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this