Transfusion-associated graft versus host disease in the immunocompetent patient: An ongoing problem

Randeep S. Jawa, David H. Young, Joseph Clarke Stothert Jr, Mahmoud N. Kulaylat, James D. Landmark

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Transfusion associated-graft versus host disease (TA-GVHD) is a rare complication of blood transfusion. It carries a very high mortality rate. Although the phenomenon has been well described in immunocompromised patients, this review focuses on the immunocompetent host. Cases of TA-GVHD continue to be reported following a variety of surgical procedures, especially cardiac procedures requiring cardiopulmonary bypass. Additional risk factors for TA-GVHD include blood component transfusion in populations with limited genetic diversity, the use of directed donations from family members, and the transfusion of fresh blood. As there is no effective treatment, the focus is on prevention.

Original languageEnglish (US)
Pages (from-to)123-130
Number of pages8
JournalJournal of Intensive Care Medicine
Volume30
Issue number3
DOIs
StatePublished - Mar 4 2015

Fingerprint

Graft vs Host Disease
Blood Transfusion
Directed Tissue Donation
Blood Component Transfusion
Cardiac Surgical Procedures
Immunocompromised Host
Cardiopulmonary Bypass
Mortality
Population
Therapeutics

Keywords

  • TA-GVHD
  • graft versus host disease
  • microchimerism
  • transfusion

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Transfusion-associated graft versus host disease in the immunocompetent patient : An ongoing problem. / Jawa, Randeep S.; Young, David H.; Stothert Jr, Joseph Clarke; Kulaylat, Mahmoud N.; Landmark, James D.

In: Journal of Intensive Care Medicine, Vol. 30, No. 3, 04.03.2015, p. 123-130.

Research output: Contribution to journalReview article

Jawa, Randeep S. ; Young, David H. ; Stothert Jr, Joseph Clarke ; Kulaylat, Mahmoud N. ; Landmark, James D. / Transfusion-associated graft versus host disease in the immunocompetent patient : An ongoing problem. In: Journal of Intensive Care Medicine. 2015 ; Vol. 30, No. 3. pp. 123-130.
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