Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7

T. J. Stivrins, R. B. Davis, Warren G Sanger, J. Fritz, D. T. Purtilo

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Two sisters in whom a diagnosis of Fanconi's anemia was made at ages 12 and 18 subsequently developed acute nonlymphocytic leukemia (ANLL). A third sibling had previously died at age 11 of apparent sepsis. Both sisters had cytogenetic studies that showed increased chromosomal breakage and a 46,XX karyotype, but subsequently developed ANLL after, or coincident with, the emergence of monosomy 7. These observations suggest that, in addition to myelodysplastic syndromes and defective neutrophil chemotaxis, monosomy 7 may be associated with the emergence of leukemia in this disorder.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalBlood
Volume64
Issue number1
StatePublished - Aug 30 1984

Fingerprint

Fanconi Anemia
Acute Myeloid Leukemia
Chromosome Breakage
Myelodysplastic Syndromes
Chemotaxis
Karyotype
Cytogenetics
Sepsis
Leukemia
Neutrophils
Monosomy Chromosome 7

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Stivrins, T. J., Davis, R. B., Sanger, W. G., Fritz, J., & Purtilo, D. T. (1984). Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7. Blood, 64(1), 173-176.

Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7. / Stivrins, T. J.; Davis, R. B.; Sanger, Warren G; Fritz, J.; Purtilo, D. T.

In: Blood, Vol. 64, No. 1, 30.08.1984, p. 173-176.

Research output: Contribution to journalArticle

Stivrins, TJ, Davis, RB, Sanger, WG, Fritz, J & Purtilo, DT 1984, 'Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7', Blood, vol. 64, no. 1, pp. 173-176.
Stivrins TJ, Davis RB, Sanger WG, Fritz J, Purtilo DT. Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7. Blood. 1984 Aug 30;64(1):173-176.
Stivrins, T. J. ; Davis, R. B. ; Sanger, Warren G ; Fritz, J. ; Purtilo, D. T. / Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7. In: Blood. 1984 ; Vol. 64, No. 1. pp. 173-176.
@article{3384d217feda4569893b41cc27f55d83,
title = "Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7",
abstract = "Two sisters in whom a diagnosis of Fanconi's anemia was made at ages 12 and 18 subsequently developed acute nonlymphocytic leukemia (ANLL). A third sibling had previously died at age 11 of apparent sepsis. Both sisters had cytogenetic studies that showed increased chromosomal breakage and a 46,XX karyotype, but subsequently developed ANLL after, or coincident with, the emergence of monosomy 7. These observations suggest that, in addition to myelodysplastic syndromes and defective neutrophil chemotaxis, monosomy 7 may be associated with the emergence of leukemia in this disorder.",
author = "Stivrins, {T. J.} and Davis, {R. B.} and Sanger, {Warren G} and J. Fritz and Purtilo, {D. T.}",
year = "1984",
month = "8",
day = "30",
language = "English (US)",
volume = "64",
pages = "173--176",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "1",

}

TY - JOUR

T1 - Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7

AU - Stivrins, T. J.

AU - Davis, R. B.

AU - Sanger, Warren G

AU - Fritz, J.

AU - Purtilo, D. T.

PY - 1984/8/30

Y1 - 1984/8/30

N2 - Two sisters in whom a diagnosis of Fanconi's anemia was made at ages 12 and 18 subsequently developed acute nonlymphocytic leukemia (ANLL). A third sibling had previously died at age 11 of apparent sepsis. Both sisters had cytogenetic studies that showed increased chromosomal breakage and a 46,XX karyotype, but subsequently developed ANLL after, or coincident with, the emergence of monosomy 7. These observations suggest that, in addition to myelodysplastic syndromes and defective neutrophil chemotaxis, monosomy 7 may be associated with the emergence of leukemia in this disorder.

AB - Two sisters in whom a diagnosis of Fanconi's anemia was made at ages 12 and 18 subsequently developed acute nonlymphocytic leukemia (ANLL). A third sibling had previously died at age 11 of apparent sepsis. Both sisters had cytogenetic studies that showed increased chromosomal breakage and a 46,XX karyotype, but subsequently developed ANLL after, or coincident with, the emergence of monosomy 7. These observations suggest that, in addition to myelodysplastic syndromes and defective neutrophil chemotaxis, monosomy 7 may be associated with the emergence of leukemia in this disorder.

UR - http://www.scopus.com/inward/record.url?scp=0021241723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021241723&partnerID=8YFLogxK

M3 - Article

VL - 64

SP - 173

EP - 176

JO - Blood

JF - Blood

SN - 0006-4971

IS - 1

ER -