Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines

Yutaka Tagaya, Yoshihisa Taniguchi, Mayumi Naramura, Masafumi Okada, Noboru Suzuki, Hiroshi Kanamori, Toshio Nikaido, Tasuku Honjo, Junji Yodoi

Research output: Contribution to journalArticle

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Abstract

In HTLV-I transformed T-cell lines established from the patients with adult T-cell leukemia (ATL), there is a constitutive activation of the normal IL-2 receptor (IL-2-R) gene. These cell lines continuously produce an ATL-derived factor (ADF), an IL-2-R inducing factor without IL-2 activity. ADF enhances the expression of the IL-2-R through the augmentation of the IL-2-R mRNA in the HTLV-I(+) T-cell line (ED) as well as the NK cell line cells (YT). In YT cells, the transcriptional initiation of the promoter of the IL-2-R gene was enhanced by ADF but not by IL-2. Production of ADF by HTLV-I(+) T-cell lines may be involved in the abnormal expression of IL-2-Rs on these cells.

Original languageEnglish (US)
Pages (from-to)221-228
Number of pages8
JournalImmunology Letters
Volume15
Issue number3
DOIs
StatePublished - Jan 1 1987

Fingerprint

Human T-lymphotropic virus 1
Interleukin-2 Receptors
T-Lymphocytes
Cell Line
Interleukin-2
Genes
Adult T Cell Leukemia Lymphoma
Transformed Cell Line
Natural Killer Cells
adult T cell leukemia-derived factor
Messenger RNA

Keywords

  • ADF
  • ATL
  • IL-2 receptor
  • Interleukin-2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Tagaya, Y., Taniguchi, Y., Naramura, M., Okada, M., Suzuki, N., Kanamori, H., ... Yodoi, J. (1987). Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines. Immunology Letters, 15(3), 221-228. https://doi.org/10.1016/0165-2478(87)90028-9

Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines. / Tagaya, Yutaka; Taniguchi, Yoshihisa; Naramura, Mayumi; Okada, Masafumi; Suzuki, Noboru; Kanamori, Hiroshi; Nikaido, Toshio; Honjo, Tasuku; Yodoi, Junji.

In: Immunology Letters, Vol. 15, No. 3, 01.01.1987, p. 221-228.

Research output: Contribution to journalArticle

Tagaya, Y, Taniguchi, Y, Naramura, M, Okada, M, Suzuki, N, Kanamori, H, Nikaido, T, Honjo, T & Yodoi, J 1987, 'Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines', Immunology Letters, vol. 15, no. 3, pp. 221-228. https://doi.org/10.1016/0165-2478(87)90028-9
Tagaya, Yutaka ; Taniguchi, Yoshihisa ; Naramura, Mayumi ; Okada, Masafumi ; Suzuki, Noboru ; Kanamori, Hiroshi ; Nikaido, Toshio ; Honjo, Tasuku ; Yodoi, Junji. / Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines. In: Immunology Letters. 1987 ; Vol. 15, No. 3. pp. 221-228.
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