Transcription factor expression during pancreatic islet regeneration

Marcie R. Kritzik, Troy Krahl, Augusta Good, Michelle Krakowski, Luc St.-Onge, Peter Gruss, Christopher Wright, Nora E Sarvetnick

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Recent studies by a number of laboratories have identified transcription factors that are involved in pancreatic development. Indeed, marked abnormalities in pancreatic development result from deficiencies in these molecules, which include, among others, PDX-1, islet-1 (Isl-1), and Pax-6. These studies have prompted us to evaluate the expression of Isl-1 and Pax-6 in the pancreas of the interferon-gamma (IFNγ) transgenic mouse, which exhibits new islet growth and expansion of ducts throughout the life of the animal. We have previously demonstrated that PDX-1 is strikingly expressed in the ducts of the IFNγ transgenic mouse. This latter observation compelled us to examine expression of hepatocyte nuclear factor-3beta (HNF3β), which mediates PDX-1 gene transcription, in the IFNγ transgenic pancreas as well. As a result of these studies, we now demonstrate marked expression of these transcription factors in the pancreatic ducts of IFNγ transgenic mice. These data suggest a role for these transcription factors during pancreatic regeneration in the IFNγ transgenic mouse. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume164
Issue number1-2
DOIs
StatePublished - Jun 20 2000
Externally publishedYes

Fingerprint

Islets of Langerhans
Interferon-gamma
Regeneration
Transcription Factors
Transgenic Mice
Ducts
Hepatocyte Nuclear Factor 3-beta
Pancreas
Pancreatic Ducts
Transcription
Animals
Genes
Observation
Molecules
Growth

Keywords

  • Hepatocyte nuclear factor-3beta
  • Islet-1
  • Pancreas
  • Pax-6
  • Regeneration

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Transcription factor expression during pancreatic islet regeneration. / Kritzik, Marcie R.; Krahl, Troy; Good, Augusta; Krakowski, Michelle; St.-Onge, Luc; Gruss, Peter; Wright, Christopher; Sarvetnick, Nora E.

In: Molecular and Cellular Endocrinology, Vol. 164, No. 1-2, 20.06.2000, p. 99-107.

Research output: Contribution to journalArticle

Kritzik, MR, Krahl, T, Good, A, Krakowski, M, St.-Onge, L, Gruss, P, Wright, C & Sarvetnick, NE 2000, 'Transcription factor expression during pancreatic islet regeneration', Molecular and Cellular Endocrinology, vol. 164, no. 1-2, pp. 99-107. https://doi.org/10.1016/S0303-7207(00)00234-3
Kritzik MR, Krahl T, Good A, Krakowski M, St.-Onge L, Gruss P et al. Transcription factor expression during pancreatic islet regeneration. Molecular and Cellular Endocrinology. 2000 Jun 20;164(1-2):99-107. https://doi.org/10.1016/S0303-7207(00)00234-3
Kritzik, Marcie R. ; Krahl, Troy ; Good, Augusta ; Krakowski, Michelle ; St.-Onge, Luc ; Gruss, Peter ; Wright, Christopher ; Sarvetnick, Nora E. / Transcription factor expression during pancreatic islet regeneration. In: Molecular and Cellular Endocrinology. 2000 ; Vol. 164, No. 1-2. pp. 99-107.
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