Transactivation of human immunodeficiency virus promoter by human herpesvirus 6

R. T. Horvat, Charles Wood, N. Balachandran

Research output: Contribution to journalArticle

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Abstract

Patients with acquired immunodeficiency syndrome (AIDS) are often infected with a number of other heterologous viruses in addition to the initial human immunodeficiency virus (HIV) infection, and these agents could act as potential reactivating agents of latent HIV. A new antigenically distinct herpesvirus, designated human herpesvirus 6 (HHV-6), has recently been isolated from patients with AIDS and has since been shown to infect a number of different human cells, specifically human T cells, B cells, and glial cells. Since these are some of the same cells that harbor the AIDS virus, it is quite important to determine any interaction between this new herpesvirus and HIV. In this report, we demonstrate that HHV-6 can trans-activate the HIV promoter in human T-cell lines as measured by the expression of the bacterial gene chloramphenicol acetyltransferase. This indicates that stimulation of HIV gene expression by HHV-6 could play a role in HIV pathogenesis.

Original languageEnglish (US)
Pages (from-to)970-973
Number of pages4
JournalJournal of virology
Volume63
Issue number2
StatePublished - Jan 1 1989

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Human herpesvirus 6
Human Herpesvirus 6
Human immunodeficiency virus
transcriptional activation
Transcriptional Activation
acquired immunodeficiency syndrome
promoter regions
HIV
Herpesviridae
T-lymphocytes
chloramphenicol acetyltransferase
viruses
Acquired Immunodeficiency Syndrome
neuroglia
HIV infections
T-Lymphocytes
Bacterial Genes
B-lymphocytes
Chloramphenicol O-Acetyltransferase
pathogenesis

ASJC Scopus subject areas

  • Immunology

Cite this

Transactivation of human immunodeficiency virus promoter by human herpesvirus 6. / Horvat, R. T.; Wood, Charles; Balachandran, N.

In: Journal of virology, Vol. 63, No. 2, 01.01.1989, p. 970-973.

Research output: Contribution to journalArticle

Horvat, R. T. ; Wood, Charles ; Balachandran, N. / Transactivation of human immunodeficiency virus promoter by human herpesvirus 6. In: Journal of virology. 1989 ; Vol. 63, No. 2. pp. 970-973.
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