Trafficking cascades mediated by Rab35 and its membrane hub effector, MICAL-L1

Sai Srinivas Panapakkam Giridharan, Bishuang Cai, Naava Naslavsky, Steven H Caplan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Various receptors navigate through the endocytic recycling compartment (ERC) on route to the plasma membrane. They are transported through recycling endosomes that emanate from the ERC that display distinct tubular morphology. A key question in the field is how the trafficking via these endosomes is regulated and how regulatory proteins such as Rab35, Rab8, Arf6 and EHD1 control this trafficking. Recent studies point to the protein MICAL-L1 as a major scaffold for these regulators. MICAL-L1 not only localizes to these tubular recycling endosomes and regulates trafficking, but it also controls the localization of EHD1 and Rab8 to these structures. It also connects its associated membranes to the motor proteins dynein and kinesin through its binding partner, CRMP2. Our recent study promotes MICAL-L1 as a Rab35 effector, where Rab35, both directly and indirectly through Arf6, controls the localization of MICAL-L1 and Rab8 to tubular membranes. We find that MICAL-L1 is a multi-tasking scaffold connecting various proteins to recycling endosomes for efficient trafficking.

Original languageEnglish (US)
Pages (from-to)384-387
Number of pages4
JournalCommunicative and Integrative Biology
Volume5
Issue number4
DOIs
StatePublished - Jan 1 2012

Fingerprint

Endosomes
endosomes
recycling
Membranes
Proteins
Dyneins
Kinesin
kinesin
proteins
regulatory proteins
Cell Membrane
plasma membrane
receptors

Keywords

  • Arf6
  • Endocytic recycling compartment
  • MICAL-L1
  • Rab35
  • Rab8
  • Tubular endosomes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Trafficking cascades mediated by Rab35 and its membrane hub effector, MICAL-L1. / Giridharan, Sai Srinivas Panapakkam; Cai, Bishuang; Naslavsky, Naava; Caplan, Steven H.

In: Communicative and Integrative Biology, Vol. 5, No. 4, 01.01.2012, p. 384-387.

Research output: Contribution to journalArticle

@article{066148dfbb314fa1b0767e6f00c06581,
title = "Trafficking cascades mediated by Rab35 and its membrane hub effector, MICAL-L1",
abstract = "Various receptors navigate through the endocytic recycling compartment (ERC) on route to the plasma membrane. They are transported through recycling endosomes that emanate from the ERC that display distinct tubular morphology. A key question in the field is how the trafficking via these endosomes is regulated and how regulatory proteins such as Rab35, Rab8, Arf6 and EHD1 control this trafficking. Recent studies point to the protein MICAL-L1 as a major scaffold for these regulators. MICAL-L1 not only localizes to these tubular recycling endosomes and regulates trafficking, but it also controls the localization of EHD1 and Rab8 to these structures. It also connects its associated membranes to the motor proteins dynein and kinesin through its binding partner, CRMP2. Our recent study promotes MICAL-L1 as a Rab35 effector, where Rab35, both directly and indirectly through Arf6, controls the localization of MICAL-L1 and Rab8 to tubular membranes. We find that MICAL-L1 is a multi-tasking scaffold connecting various proteins to recycling endosomes for efficient trafficking.",
keywords = "Arf6, Endocytic recycling compartment, MICAL-L1, Rab35, Rab8, Tubular endosomes",
author = "Giridharan, {Sai Srinivas Panapakkam} and Bishuang Cai and Naava Naslavsky and Caplan, {Steven H}",
year = "2012",
month = "1",
day = "1",
doi = "10.4161/cib.20064",
language = "English (US)",
volume = "5",
pages = "384--387",
journal = "Communicative and Integrative Biology",
issn = "1942-0889",
publisher = "Landes Bioscience",
number = "4",

}

TY - JOUR

T1 - Trafficking cascades mediated by Rab35 and its membrane hub effector, MICAL-L1

AU - Giridharan, Sai Srinivas Panapakkam

AU - Cai, Bishuang

AU - Naslavsky, Naava

AU - Caplan, Steven H

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Various receptors navigate through the endocytic recycling compartment (ERC) on route to the plasma membrane. They are transported through recycling endosomes that emanate from the ERC that display distinct tubular morphology. A key question in the field is how the trafficking via these endosomes is regulated and how regulatory proteins such as Rab35, Rab8, Arf6 and EHD1 control this trafficking. Recent studies point to the protein MICAL-L1 as a major scaffold for these regulators. MICAL-L1 not only localizes to these tubular recycling endosomes and regulates trafficking, but it also controls the localization of EHD1 and Rab8 to these structures. It also connects its associated membranes to the motor proteins dynein and kinesin through its binding partner, CRMP2. Our recent study promotes MICAL-L1 as a Rab35 effector, where Rab35, both directly and indirectly through Arf6, controls the localization of MICAL-L1 and Rab8 to tubular membranes. We find that MICAL-L1 is a multi-tasking scaffold connecting various proteins to recycling endosomes for efficient trafficking.

AB - Various receptors navigate through the endocytic recycling compartment (ERC) on route to the plasma membrane. They are transported through recycling endosomes that emanate from the ERC that display distinct tubular morphology. A key question in the field is how the trafficking via these endosomes is regulated and how regulatory proteins such as Rab35, Rab8, Arf6 and EHD1 control this trafficking. Recent studies point to the protein MICAL-L1 as a major scaffold for these regulators. MICAL-L1 not only localizes to these tubular recycling endosomes and regulates trafficking, but it also controls the localization of EHD1 and Rab8 to these structures. It also connects its associated membranes to the motor proteins dynein and kinesin through its binding partner, CRMP2. Our recent study promotes MICAL-L1 as a Rab35 effector, where Rab35, both directly and indirectly through Arf6, controls the localization of MICAL-L1 and Rab8 to tubular membranes. We find that MICAL-L1 is a multi-tasking scaffold connecting various proteins to recycling endosomes for efficient trafficking.

KW - Arf6

KW - Endocytic recycling compartment

KW - MICAL-L1

KW - Rab35

KW - Rab8

KW - Tubular endosomes

UR - http://www.scopus.com/inward/record.url?scp=84898471180&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898471180&partnerID=8YFLogxK

U2 - 10.4161/cib.20064

DO - 10.4161/cib.20064

M3 - Article

VL - 5

SP - 384

EP - 387

JO - Communicative and Integrative Biology

JF - Communicative and Integrative Biology

SN - 1942-0889

IS - 4

ER -