Toxicology of protein allergenicity

Prediction and characterization

I. Kimber, N. I. Kerkvliet, Stephen L Taylor, J. D. Astwood, K. Sarlo, R. J. Dearman

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

The ability of exogenous proteins to cause respiratory and gastrointestinal allergy, and sometimes systemic anaphylactic reactions, is well known. What is not clear however, are the properties that confer on proteins the ability to induce allergic sensitization. With an expansion in the use of enzymes for industrial applications and consumer products, and a substantial and growing investment in the development of transgenic crop plants that express novel proteins introduced from other sources, the issue of protein allergenicity has assumed considerable toxicological significance. There is a need now for methods that will allow the accurate identification and characterization of potential protein allergens and for estimation of relative potency as a first step towards risk assessment. To address some of these issues, and to review progress that has been made in the toxicological investigation of respiratory and gastrointestinal allergy induced by proteins, a workshop, entitled the Toxicology of Protein Allergenicity: Prediction and Characterization, was convened at the 37th Annual Conference of the Society of Toxicology in Seattle, Washington (1998). The subject of protein allergenicity is considered here in the context of presentations made at that workshop.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalToxicological Sciences
Volume48
Issue number2
DOIs
StatePublished - May 25 1999

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Toxicology
Proteins
Allergies
Hypersensitivity
Education
Consumer products
Genetically Modified Plants
Anaphylaxis
Risk assessment
Allergens
Industrial applications
Crops
Enzymes

ASJC Scopus subject areas

  • Toxicology

Cite this

Kimber, I., Kerkvliet, N. I., Taylor, S. L., Astwood, J. D., Sarlo, K., & Dearman, R. J. (1999). Toxicology of protein allergenicity: Prediction and characterization. Toxicological Sciences, 48(2), 157-162. https://doi.org/10.1093/toxsci/48.2.157

Toxicology of protein allergenicity : Prediction and characterization. / Kimber, I.; Kerkvliet, N. I.; Taylor, Stephen L; Astwood, J. D.; Sarlo, K.; Dearman, R. J.

In: Toxicological Sciences, Vol. 48, No. 2, 25.05.1999, p. 157-162.

Research output: Contribution to journalReview article

Kimber, I, Kerkvliet, NI, Taylor, SL, Astwood, JD, Sarlo, K & Dearman, RJ 1999, 'Toxicology of protein allergenicity: Prediction and characterization', Toxicological Sciences, vol. 48, no. 2, pp. 157-162. https://doi.org/10.1093/toxsci/48.2.157
Kimber, I. ; Kerkvliet, N. I. ; Taylor, Stephen L ; Astwood, J. D. ; Sarlo, K. ; Dearman, R. J. / Toxicology of protein allergenicity : Prediction and characterization. In: Toxicological Sciences. 1999 ; Vol. 48, No. 2. pp. 157-162.
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