Toxic and nontoxic changes induced in the urothelium by xenobiotics

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Urothelial carcinogenesis progresses through several morphologically identifiable stages from simple hyperplasia, to nodular and papillary hyperplasia, to papilloma, and to noninvasive and invasive carcinoma. Unfortunately, no specific identifiable markers on any of the early lesions are available to distinguish those which will become neoplasms from those that are potentially reversible. Urothelial toxicity secondary to cyclophosphamide injection also progresses through several phases, beginning with vacuolization of the epithelium, to necrosis and ulceration, followed by an inflammatory infiltrate, granulation tissue formation, and marked regenerative hyperplasia of the epithelium, with ultimate repair and return to normal. Numerous changes related to toxicity are similar to those seen during carcinogenesis. In addition, several apparent morphologic "changes" occurring in the adult bladder can be mistaken for evidence of toxicity, and more importantly, many of the changes seen during regenerative repair and during carcinogenesis occur in the normal fetal urothelial development.

Original languageEnglish (US)
Pages (from-to)484-498
Number of pages15
JournalToxicology and Applied Pharmacology
Volume101
Issue number3
DOIs
StatePublished - Dec 1989

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Urothelium
Poisons
Xenobiotics
Hyperplasia
Toxicity
Carcinogenesis
Repair
Epithelium
Granulation
Granulation Tissue
Papilloma
Fetal Development
Cyclophosphamide
Urinary Bladder
Necrosis
Tissue
Carcinoma
Injections
Neoplasms

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Toxic and nontoxic changes induced in the urothelium by xenobiotics. / Cohen, Samuel Monroe.

In: Toxicology and Applied Pharmacology, Vol. 101, No. 3, 12.1989, p. 484-498.

Research output: Contribution to journalArticle

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