Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycle

Clinton Jones, Guey Chuen Perng

Research output: Contribution to journalReview article

63 Citations (Scopus)

Abstract

Infection by herpes simplex virus type 1 (HSV-1) can cause clinical symptoms in the peripheral and central nervous system. Recurrent ocular shedding can lead to corneal scarring and vision loss making HSV-1 a leading cause of corneal blindness due to an infectious agent. The primary site of HSV-1 latency is sensory neurons within trigeminal ganglia. Periodically, reactivation from latency occurs resulting in virus transmission and recurrent disease. During latency, the latency-associated transcript (LAT) is abundantly expressed. LAT expression is important for the latency-reactivation cycle in animal models, in part, because it inhibits apoptosis, viral gene expression, and productive infection. A novel transcript within LAT coding sequences (AL3) and small nonprotein coding RNAs are also expressed in trigeminal ganglia of latently infected mice. In this review, an update of viral factors that are expressed during latency and their potential roles in regulating the latency-reactivation cycle is discussed.

Original languageEnglish (US)
Article number262415
JournalInterdisciplinary Perspectives on Infectious Diseases
Volume2010
DOIs
StatePublished - Apr 22 2010

Fingerprint

Virus Latency
Human Herpesvirus 1
Trigeminal Ganglion
Viral Genes
Peripheral Nervous System
Sensory Receptor Cells
Blindness
Infection
Cicatrix
Central Nervous System
Animal Models
RNA
Apoptosis
Viruses
Gene Expression

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Cite this

Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycle. / Jones, Clinton; Perng, Guey Chuen.

In: Interdisciplinary Perspectives on Infectious Diseases, Vol. 2010, 262415, 22.04.2010.

Research output: Contribution to journalReview article

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