Total synthesis of (±)-Marinopyrrole a and its library as potential antibiotic and anticancer agents

Chunwei Cheng, Lili Pan, Yi Chen, Hao Song, Yong Qin, Rongshi Li

Research output: Contribution to journalArticle

44 Scopus citations


The first total synthesis of marine natural product, (±)- marinopyrrole A, has been accomplished via a nine-step synthesis in an overall yield of 30%. A small focused library based on marinopyrrole has been designed and synthesized. The scope of chemistry was investigated, and a robust chemistry suitable for library synthesis has been developed in the current study. The method that we have developed has made it possible to generate diverse analogues based on structurally novel marinopyrroles for study of potential antibiotic and anticancer activities.

Original languageEnglish (US)
Pages (from-to)541-547
Number of pages7
JournalJournal of Combinatorial Chemistry
Issue number4
StatePublished - Jul 12 2010


ASJC Scopus subject areas

  • Chemistry(all)

Cite this