Topical superoxide dismutase in posttreatment fibrosis in patients with head and neck cancer

Kelly C. Landeen, William Spanos, Laurie Gromer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Topical superoxide dismutase (SOD) has been shown to decrease postradiation fibrosis in some cancers but has not demonstrated an effect in patients with head and neck cancer. The purpose of this study was to determine if topical SOD is an effective treatment for postradiation neck fibrosis. Methods: This was a randomized prospective blinded clinical study of topical SOD versus placebo for the treatment of neck fibrosis. Measures of fibrosis grade and quality of life were obtained at baseline and after 3 months of treatment. Results: Improvement in fibrosis score was comparable between the 2 study arms at 3 months. Conclusion: Both study groups showed improvement but the differences between groups was not statistically significant. Topical SOD likely has limited benefit for posttreatment neck fibrosis but this study confirms other published evidence of benefit from active physical therapy of posttreatment fibrosis in patients with head and neck cancer.

Original languageEnglish (US)
Pages (from-to)1400-1405
Number of pages6
JournalHead and Neck
Volume40
Issue number7
DOIs
StatePublished - Jul 1 2018
Externally publishedYes

Fingerprint

Head and Neck Neoplasms
Superoxide Dismutase
Fibrosis
Neck
Therapeutics
Arm
Placebos
Quality of Life
Neoplasms

Keywords

  • fibrosis
  • head and neck cancer
  • quality of life
  • radiation
  • superoxide dismutase

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Topical superoxide dismutase in posttreatment fibrosis in patients with head and neck cancer. / Landeen, Kelly C.; Spanos, William; Gromer, Laurie.

In: Head and Neck, Vol. 40, No. 7, 01.07.2018, p. 1400-1405.

Research output: Contribution to journalArticle

Landeen, Kelly C. ; Spanos, William ; Gromer, Laurie. / Topical superoxide dismutase in posttreatment fibrosis in patients with head and neck cancer. In: Head and Neck. 2018 ; Vol. 40, No. 7. pp. 1400-1405.
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