Toll-like receptors in central nervous system glial inflammation and homeostasis

Research output: Contribution to journalReview article

219 Citations (Scopus)

Abstract

Toll-like receptors (TLRs) are a family of pattern-recognition receptors expressed on cells of the innate immune system that allow for the recognition of conserved structural motifs on a wide array of pathogens, referred to as pathogen-associated molecular patterns, as well as some endogenous molecules. The recent emergence of studies examining TLRs in the central nervous system (CNS) indicates that these receptors not only play a role in innate immunity in response to infectious diseases but may also participate in CNS autoimmunity, neurodegeneration, and tissue injury. This review summarizes the experimental evidence demonstrating a role for TLRs in the context of CNS inflammation in both infectious and noninfectious conditions.

Original languageEnglish (US)
Pages (from-to)711-730
Number of pages20
JournalJournal of Neuroscience Research
Volume83
Issue number5
DOIs
StatePublished - Apr 1 2006

Fingerprint

Toll-Like Receptors
Neuroglia
Homeostasis
Central Nervous System
Inflammation
Pattern Recognition Receptors
Autoimmunity
Innate Immunity
Communicable Diseases
Immune System
Wounds and Injuries

Keywords

  • Central nervous system
  • Pathogen-associated molecular pattern (PAMP)
  • Pattern recognition receptor (PRR)
  • Toll-like receptor (TLR)

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Toll-like receptors in central nervous system glial inflammation and homeostasis. / Kielian, Tammy.

In: Journal of Neuroscience Research, Vol. 83, No. 5, 01.04.2006, p. 711-730.

Research output: Contribution to journalReview article

@article{3e7f955e4e69488aafcfe8c14ed203ac,
title = "Toll-like receptors in central nervous system glial inflammation and homeostasis",
abstract = "Toll-like receptors (TLRs) are a family of pattern-recognition receptors expressed on cells of the innate immune system that allow for the recognition of conserved structural motifs on a wide array of pathogens, referred to as pathogen-associated molecular patterns, as well as some endogenous molecules. The recent emergence of studies examining TLRs in the central nervous system (CNS) indicates that these receptors not only play a role in innate immunity in response to infectious diseases but may also participate in CNS autoimmunity, neurodegeneration, and tissue injury. This review summarizes the experimental evidence demonstrating a role for TLRs in the context of CNS inflammation in both infectious and noninfectious conditions.",
keywords = "Central nervous system, Pathogen-associated molecular pattern (PAMP), Pattern recognition receptor (PRR), Toll-like receptor (TLR)",
author = "Tammy Kielian",
year = "2006",
month = "4",
day = "1",
doi = "10.1002/jnr.20767",
language = "English (US)",
volume = "83",
pages = "711--730",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
publisher = "Wiley-Liss Inc.",
number = "5",

}

TY - JOUR

T1 - Toll-like receptors in central nervous system glial inflammation and homeostasis

AU - Kielian, Tammy

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Toll-like receptors (TLRs) are a family of pattern-recognition receptors expressed on cells of the innate immune system that allow for the recognition of conserved structural motifs on a wide array of pathogens, referred to as pathogen-associated molecular patterns, as well as some endogenous molecules. The recent emergence of studies examining TLRs in the central nervous system (CNS) indicates that these receptors not only play a role in innate immunity in response to infectious diseases but may also participate in CNS autoimmunity, neurodegeneration, and tissue injury. This review summarizes the experimental evidence demonstrating a role for TLRs in the context of CNS inflammation in both infectious and noninfectious conditions.

AB - Toll-like receptors (TLRs) are a family of pattern-recognition receptors expressed on cells of the innate immune system that allow for the recognition of conserved structural motifs on a wide array of pathogens, referred to as pathogen-associated molecular patterns, as well as some endogenous molecules. The recent emergence of studies examining TLRs in the central nervous system (CNS) indicates that these receptors not only play a role in innate immunity in response to infectious diseases but may also participate in CNS autoimmunity, neurodegeneration, and tissue injury. This review summarizes the experimental evidence demonstrating a role for TLRs in the context of CNS inflammation in both infectious and noninfectious conditions.

KW - Central nervous system

KW - Pathogen-associated molecular pattern (PAMP)

KW - Pattern recognition receptor (PRR)

KW - Toll-like receptor (TLR)

UR - http://www.scopus.com/inward/record.url?scp=33645322938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645322938&partnerID=8YFLogxK

U2 - 10.1002/jnr.20767

DO - 10.1002/jnr.20767

M3 - Review article

C2 - 16541438

AN - SCOPUS:33645322938

VL - 83

SP - 711

EP - 730

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 5

ER -