Toll-like receptors in central nervous system glial inflammation and homeostasis

Research output: Contribution to journalReview article

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Abstract

Toll-like receptors (TLRs) are a family of pattern-recognition receptors expressed on cells of the innate immune system that allow for the recognition of conserved structural motifs on a wide array of pathogens, referred to as pathogen-associated molecular patterns, as well as some endogenous molecules. The recent emergence of studies examining TLRs in the central nervous system (CNS) indicates that these receptors not only play a role in innate immunity in response to infectious diseases but may also participate in CNS autoimmunity, neurodegeneration, and tissue injury. This review summarizes the experimental evidence demonstrating a role for TLRs in the context of CNS inflammation in both infectious and noninfectious conditions.

Original languageEnglish (US)
Pages (from-to)711-730
Number of pages20
JournalJournal of Neuroscience Research
Volume83
Issue number5
DOIs
StatePublished - Apr 1 2006

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Keywords

  • Central nervous system
  • Pathogen-associated molecular pattern (PAMP)
  • Pattern recognition receptor (PRR)
  • Toll-like receptor (TLR)

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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