Toll-like receptor (TLR) and inflammasome actions in the central nervous system

Richa Hanamsagar, Mark L. Hanke, Tammy L Kielian

Research output: Contribution to journalReview article

110 Citations (Scopus)

Abstract

During the past 10 years, much attention has been focused towards elucidating the impact of Toll-like receptors (TLRs) in central nervous system (CNS) innate immunity. TLR signaling triggers the transcriptional activation of pro-interleukin-1β (pro-IL-1β) and pro-IL-18 that are processed into their active forms by the inflammasome. Recent studies have demonstrated inflammasome involvement during CNS infection, autoimmune disease, and injury. This review will address inflammasome actions within the CNS and how cooperation between TLR and inflammasome signaling may influence disease outcome. In addition, the concept of alternative inflammasome functions independent of IL-1 and IL-18 processing are considered in the context of CNS disease.

Original languageEnglish (US)
Pages (from-to)333-342
Number of pages10
JournalTrends in Immunology
Volume33
Issue number7
DOIs
StatePublished - Jul 1 2012

Fingerprint

Inflammasomes
Toll-Like Receptors
Central Nervous System
Interleukin-18
Interleukin-1
Autoimmune Diseases of the Nervous System
Central Nervous System Infections
Central Nervous System Diseases
Innate Immunity
Transcriptional Activation
Wounds and Injuries

Keywords

  • Bacterial meningitis
  • Brain abscess
  • IL-18
  • IL-1β
  • Inflammasome
  • Microglia
  • Neurodegeneration
  • Toll-like receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Toll-like receptor (TLR) and inflammasome actions in the central nervous system. / Hanamsagar, Richa; Hanke, Mark L.; Kielian, Tammy L.

In: Trends in Immunology, Vol. 33, No. 7, 01.07.2012, p. 333-342.

Research output: Contribution to journalReview article

Hanamsagar, Richa ; Hanke, Mark L. ; Kielian, Tammy L. / Toll-like receptor (TLR) and inflammasome actions in the central nervous system. In: Trends in Immunology. 2012 ; Vol. 33, No. 7. pp. 333-342.
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