Titanium implant with nanostructured zirconia surface promotes maturation of peri-implant bone in osseointegration

Anand Dusad, Dennis A. Chakkalakal, Fereydoon Namavar, Hani Haider, Brock Hanisch, Michael J. Duryee, April Diaz, Adam Rensch, Yijia Zhang, Ryan Hess, Geoffrey Milton Thiele, Edward V. Fehringer

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The goal of the experiment outlined in this article is to improve upon noncemented methods of arthroplasty for clinical application in elderly patients. This was done by determining whether titanium implants with a novel nanostructured zirconia surface, which was created by ion beam-assisted deposition, would prevent impaired osseointegration of intramedullary implants in 1-year-old rats receiving a protein-deficient diet. Specifically, we asked whether the implant with the nanostructured zirconia surface would increase expression of markers of bone maturation within the remodeling of peri-implant woven bone. The control implants, which were made of commercially pure titanium, had a polished surface ex vivo but are known to acquire a microstructured titania surface in vivo. Ten 1-year-old rats received experimental implant (group A) and 10 had control (group B) implants. Ten 3-month-old rats received normal protein diet and the control implant (group C). Animals were euthanized 8 weeks after implantation, and transverse sections of femurimplant samples were used for histology, micro-computed tomography and immunohistochemical evaluations. In group B, the expression of a2b1 and a5b1 integrins, which are known to mediate osteoblast adhesion, glycosaminoglycans, heparan sulfate and chondroitin sulfate, was less than half of that in group C. Important to this study, the zirconia surface used in group A prevented these deficiencies. Therefore, these results indicate that nanostructured zirconia surface created on clinical implants by ion beam-assisted deposition may prevent impaired osseointegration in elderly patients by promoting quicker maturation of peri-implant woven bone.

Original languageEnglish (US)
Pages (from-to)510-522
Number of pages13
JournalProceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Volume227
Issue number5
DOIs
StatePublished - May 1 2013

Fingerprint

Osseointegration
Titanium
Zirconia
Bone
Bone and Bones
Ion beam assisted deposition
Rats
Experimental Implants
Ions
Nutrition
Diet
Control Groups
Heparitin Sulfate
Chondroitin Sulfates
Glycosaminoglycans
Osteoblasts
Integrins
Arthroplasty
Proteins
Histology

Keywords

  • Bone
  • Micro-computed tomography
  • Osseointegration
  • Rat implant model
  • Titanium implant
  • Zirconia oxide

ASJC Scopus subject areas

  • Mechanical Engineering

Cite this

Titanium implant with nanostructured zirconia surface promotes maturation of peri-implant bone in osseointegration. / Dusad, Anand; Chakkalakal, Dennis A.; Namavar, Fereydoon; Haider, Hani; Hanisch, Brock; Duryee, Michael J.; Diaz, April; Rensch, Adam; Zhang, Yijia; Hess, Ryan; Thiele, Geoffrey Milton; Fehringer, Edward V.

In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, Vol. 227, No. 5, 01.05.2013, p. 510-522.

Research output: Contribution to journalArticle

Dusad, Anand ; Chakkalakal, Dennis A. ; Namavar, Fereydoon ; Haider, Hani ; Hanisch, Brock ; Duryee, Michael J. ; Diaz, April ; Rensch, Adam ; Zhang, Yijia ; Hess, Ryan ; Thiele, Geoffrey Milton ; Fehringer, Edward V. / Titanium implant with nanostructured zirconia surface promotes maturation of peri-implant bone in osseointegration. In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 2013 ; Vol. 227, No. 5. pp. 510-522.
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AU - Dusad, Anand

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AU - Haider, Hani

AU - Hanisch, Brock

AU - Duryee, Michael J.

AU - Diaz, April

AU - Rensch, Adam

AU - Zhang, Yijia

AU - Hess, Ryan

AU - Thiele, Geoffrey Milton

AU - Fehringer, Edward V.

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AB - The goal of the experiment outlined in this article is to improve upon noncemented methods of arthroplasty for clinical application in elderly patients. This was done by determining whether titanium implants with a novel nanostructured zirconia surface, which was created by ion beam-assisted deposition, would prevent impaired osseointegration of intramedullary implants in 1-year-old rats receiving a protein-deficient diet. Specifically, we asked whether the implant with the nanostructured zirconia surface would increase expression of markers of bone maturation within the remodeling of peri-implant woven bone. The control implants, which were made of commercially pure titanium, had a polished surface ex vivo but are known to acquire a microstructured titania surface in vivo. Ten 1-year-old rats received experimental implant (group A) and 10 had control (group B) implants. Ten 3-month-old rats received normal protein diet and the control implant (group C). Animals were euthanized 8 weeks after implantation, and transverse sections of femurimplant samples were used for histology, micro-computed tomography and immunohistochemical evaluations. In group B, the expression of a2b1 and a5b1 integrins, which are known to mediate osteoblast adhesion, glycosaminoglycans, heparan sulfate and chondroitin sulfate, was less than half of that in group C. Important to this study, the zirconia surface used in group A prevented these deficiencies. Therefore, these results indicate that nanostructured zirconia surface created on clinical implants by ion beam-assisted deposition may prevent impaired osseointegration in elderly patients by promoting quicker maturation of peri-implant woven bone.

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KW - Titanium implant

KW - Zirconia oxide

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